Anesthetic-Induced Neurodegeneration Mediated via Inositol 1,4,5-Trisphosphate Receptors

The commonly used general anesthetic isoflurane induces widespread neurodegeneration in the developing mammalian brain through poorly understood mechanisms. We have investigated whether excessive Ca2+ release from the endoplasmic reticulum via overactivation of inositol 1,4,5-trisphosphate receptors...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2010-04, Vol.333 (1), p.14-22
Hauptverfasser:	Zhao, Yifan, Liang, Ge, Chen, Qianru, Joseph, Donald J., Meng, Qingcheng, Eckenhoff, Roderic G., Eckenhoff, Maryellen F., Wei, Huafeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Precursor Protein Secretases - metabolism Anesthetics, Inhalation - adverse effects Animals Apoptosis Aspartic Acid Endopeptidases - metabolism bcl-2-Associated X Protein - metabolism bcl-X Protein - metabolism Brain - growth & development Brain - metabolism Brain - pathology Calcium - physiology Cells, Cultured Enzyme Activation Gene Knockdown Techniques Homeostasis Inositol 1,4,5-Trisphosphate Receptors - antagonists & inhibitors Inositol 1,4,5-Trisphosphate Receptors - physiology Isoflurane - adverse effects Maze Learning - drug effects Mice Nerve Degeneration - chemically induced Nerve Degeneration - metabolism Nerve Degeneration - pathology Neurons - drug effects Neurons - metabolism Neurons - pathology Neuropharmacology Rats
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