Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2

Sphingolipid-metabolizing enzymes control the dynamic balance of the cellular levels of important bioactive lipids, including the apoptotic compound ceramide and the proliferative compound sphingosine 1-phosphate (S1P). Many growth factors and inflammatory cytokines promote the cleavage of sphingomy...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2010-04, Vol.333 (1), p.129-139
Hauptverfasser:	French, Kevin J., Zhuang, Yan, Maines, Lynn W., Gao, Peng, Wang, Wenxue, Beljanski, Vladimir, Upson, John J., Green, Cecelia L., Keller, Staci N., Smith, Charles D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - pharmacokinetics Adamantane - pharmacology Adamantane - therapeutic use Administration, Oral Animals Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Biological Availability Cell Line, Tumor Cell Proliferation - drug effects Chemotaxis - drug effects Chemotherapy, Antibiotics, and Gene Therapy Female Humans Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Neoplasm Transplantation Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors Pyridines - pharmacokinetics Pyridines - pharmacology Pyridines - therapeutic use Rats Rats, Sprague-Dawley
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