TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice

Skeletal muscle atrophy occurs in a variety of clinical settings, including cachexia, disuse, and denervation. Inflammatory cytokines have been shown to be mediators of cancer cachexia; however, the role of cytokines in denervation- and immobilization-induced skeletal muscle loss remains unknown. In...

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Veröffentlicht in:	The Journal of cell biology 2010-03, Vol.188 (6), p.833-849
Hauptverfasser:	Mittal, Ashwani, Bhatnagar, Shephali, Kumar, Akhilesh, Lach-Trifilieff, Estelle, Wauters, Sandrine, Li, Hong, Makonchuk, Denys Y, Glass, David J, Kumar, Ashok
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell growth Cytokine TWEAK Cytokines Denervation Disease Models, Animal Fibrosis Gene expression Messenger RNA Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Muscle Denervation Muscle, Skeletal - innervation Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscles Muscular atrophy Muscular Atrophy - metabolism Muscular Atrophy - pathology Musculoskeletal system Proteins Receptors Receptors, Tumor Necrosis Factor - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal transduction Skeletal muscle T cell receptors TNF inhibitors Transgenic animals Tumor Necrosis Factors - deficiency Tumor Necrosis Factors - genetics Tumor Necrosis Factors - metabolism TWEAK Receptor
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