SoDA2: a Hidden Markov Model approach for identification of immunoglobulin rearrangements

Motivation: The inference of pre-mutation immunoglobulin (Ig) rearrangements is essential in the study of the antibody repertoires produced in response to infection, in B-cell neoplasms and in autoimmune disease. Often, there are several rearrangements that are nearly equivalent as candidates for a...

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Veröffentlicht in:	Bioinformatics 2010-04, Vol.26 (7), p.867-872
Hauptverfasser:	Munshaw, Supriya, Kepler, Thomas B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence B-Lymphocytes - immunology Base Sequence Biological and medical sciences Fundamental and applied biological sciences. Psychology Gene Rearrangement, B-Lymphocyte General aspects Genes, Immunoglobulin Immunoglobulins - genetics Markov Chains Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) Molecular Sequence Data Original Papers Sequence Alignment Software
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