Increased CYP2J3 Expression Reduces Insulin Resistance in Fructose-Treated Rats and db/db Mice

Accumulating evidence suggests that cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play crucial and diverse roles in cardiovascular homeostasis. The anti-inflammatory, antihypertensive, and pro-proliferative effects of EETs suggest a possi...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2010-04, Vol.59 (4), p.997-1005
Hauptverfasser:	XIZHEN XU, CHUN XIA ZHAO, LUYUN WANG, LING TU, XIAOSAI FANG, CHANGLONG ZHENG, EDIN, Matthew L, ZELDIN, Darryl C, DAO WEN WANG
Format:	Artikel
Sprache:	eng
Schlagworte:	8,11,14-Eicosatrienoic Acid - analogs & derivatives 8,11,14-Eicosatrienoic Acid - urine Acids Animals Apoptosis Biological and medical sciences Blood Pressure Care and treatment Cholesterol Cytochrome Cytochrome P-450 Cytochrome P-450 Enzyme System - genetics Diabetes Diabetes. Impaired glucose tolerance DNA Primers Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelin-1 - genetics Enzyme-Linked Immunosorbent Assay Etiopathogenesis. Screening. Investigations. Target tissue resistance Fructose - therapeutic use Gene Expression Regulation Gene therapy Genetic aspects Glucose Glucose Tolerance Test Health aspects High density lipoprotein Homeostasis Hypertension Hypertension - genetics Hypertension - prevention & control Insulin resistance Insulin Resistance - genetics Insulin Resistance - physiology Kinases Laboratory animals Low density lipoprotein Medical sciences Metabolic Syndrome - genetics Metabolic Syndrome - prevention & control Mice Nitric Oxide Synthase Type III - genetics Original Physiological aspects Potassium Proteins Rats Reagents Receptor, Endothelin A - genetics Research design Risk factors RNA, Messenger - genetics Triglycerides Tumor necrosis factor-TNF Urine
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