Evaluation of Mucoadhesive PLGA Microparticles for Nasal Immunization

In this study, hepatitis B surface antigen (HBsAg) loaded poly(lactic-co-glycolic acid) (PLGA) microparticles were prepared and coated with chitosan and trimethyl chitosan (TMC) to evaluate the effect of coating material for nasal vaccine delivery. The developed formulations were characterized for s...

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Veröffentlicht in:	The AAPS journal 2010-06, Vol.12 (2), p.130-137
Hauptverfasser:	Pawar, Dilip, Goyal, Amit K., Mangal, Sharad, Mishra, Neeraj, Vaidya, Bhuvaneshwar, Tiwari, Shailja, Jain, Arvind K., Vyas, Suresh P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Chemistry, Pharmaceutical Chitosan Drug Carriers Electrochemistry Enzyme-Linked Immunosorbent Assay Excipients - chemistry Female Hepatitis B Surface Antigens - administration & dosage Hepatitis B Surface Antigens - immunology Immunoglobulin A - analysis Immunoglobulin A - biosynthesis Immunoglobulin G - analysis Immunoglobulin G - biosynthesis Lactic Acid - chemistry Mice Mice, Inbred BALB C Microscopy, Electron, Scanning Microscopy, Fluorescence Mucins - chemistry Nanoparticles Pharmacology/Toxicology Pharmacy Polyglycolic Acid - chemistry Research Article Tissue Adhesives Vaccines - administration & dosage
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