Targeted Inactivation of EGF Receptor Inhibits Renal Collecting Duct Development and Function

The ureteric bud (UB) expresses high levels of the EGF receptor (EGFR) during kidney development, but its function in this setting is unclear. Here, Egfr mRNA was abundant in medullary portions of the UB trunk but absent from the branching UB tips during embryogenesis. Homozygous Egfr knockout did n...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2010-04, Vol.21 (4), p.573-578
Hauptverfasser:	ZHAO ZHANG, PASCUET, Elena, HUEBER, Pierre-Alain, CHU, Leelee, BICHET, Daniel G, LEE, Tang-Cheng, THREADGILL, David W, GOODYER, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brief Communication Gene Expression Regulation, Developmental Gene Silencing Kidney Tubules, Collecting - embryology Medical sciences Mice Mice, Knockout Nephrology. Urinary tract diseases Receptor, Epidermal Growth Factor - physiology
Online-Zugang:	Volltext
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