A Residue in Loop 9 of the β2-Subunit Stabilizes the Closed State of the GABAA Receptor

In γ-aminobutyric acid type A (GABAA) receptors, the structural elements that couple ligand binding to channel opening remain poorly defined. Here, site-directed mutagenesis was used to determine if Loop 9 on the non-GABA binding site interface of the β2-subunit may be involved in GABAA receptor act...

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Veröffentlicht in:	The Journal of biological chemistry 2010-03, Vol.285 (10), p.7281-7287
Hauptverfasser:	Williams, Carrie A., Bell, Shannon V., Jenkins, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Channels/Chloride GABA Receptors Protein/Allosteric Protein/Ligand Binding Receptors/Structure-Function Signal Transduction
Online-Zugang:	Volltext
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