Pro-hormone Secretogranin II Regulates Dense Core Secretory Granule Biogenesis in Catecholaminergic Cells

Processes underlying the formation of dense core secretory granules (DCGs) of neuroendocrine cells are poorly understood. Here, we present evidence that DCG biogenesis is dependent on the secretory protein secretogranin (Sg) II, a member of the granin family of pro-hormone cargo of DCGs in neuroendo...

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Veröffentlicht in:	The Journal of biological chemistry 2010-03, Vol.285 (13), p.10030-10043
Hauptverfasser:	Courel, Maïté, Soler-Jover, Alex, Rodriguez-Flores, Juan L., Mahata, Sushil K., Elias, Salah, Montero-Hadjadje, Maïté, Anouar, Youssef, Giuly, Richard J., O'Connor, Daniel T., Taupenot, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catecholamines - metabolism Cell Biology Cell/Exocytosis Cell/pH Cell/Secretion Cellular Biology Chlorocebus aethiops Chromaffin Chromaffin Granules - metabolism COS Cells Gene Silencing Genetic Vectors Hydrogen-Ion Concentration Life Sciences Methods/Fluorescence Neuroendocrine Cells - metabolism PC12 Cells Protein/Chimeras Protein/Intracellular Trafficking Rats Recombinant Fusion Proteins - metabolism RNA, Small Interfering - metabolism Secretogranin II - metabolism Secretory Vesicles - metabolism Subcellular Organelles/Vesicles Subcellular Processes
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