HHQ and PQS, two Pseudomonas aeruginosa quorum‐sensing molecules, down‐regulate the innate immune responses through the nuclear factor‐κB pathway

Summary To explore whether bacterial secreted 4‐hydroxy‐2‐alkylquinolines (HAQs) can regulate host innate immune responses, we used the extracts of bacterial culture supernatants from a wild‐type (PA14) and two mutants of Pseudomonas aeruginosa that have defects in making HAQs. Surprisingly, the ext...

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Veröffentlicht in:	Immunology 2010-04, Vol.129 (4), p.578-588
Hauptverfasser:	Kim, Kiwan, Kim, Young Uk, Koh, Byung Hee, Hwang, Soo Seok, Kim, Seol‐Hee, Lépine, Francois, Cho, You‐Hee, Lee, Gap Ryol
Format:	Artikel
Sprache:	eng
Schlagworte:	4‐hydroxy‐2‐alkylquinolines immune evasion innate cytokine innate immunity macrophage nuclear factor‐κB Original quorum sensing
Online-Zugang:	Volltext
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