The carboxy-terminal fragment of α1A calcium channel preferentially aggregates in the cytoplasm of human spinocerebellar ataxia type 6 Purkinje cells

Spinocerebellar ataxia type 6 (SCA6) is an autosomal dominant neurodegenerative disease caused by a small polyglutamine (polyQ) expansion (control: 4–20Q; SCA6: 20–33Q) in the carboxyl(C)-terminal cytoplasmic domain of the α 1A voltage-dependent calcium channel (Ca v 2.1). Although a 75–85-kDa Ca v...

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Veröffentlicht in:	Acta neuropathologica 2010-04, Vol.119 (4), p.447-464
Hauptverfasser:	Ishiguro, Taro, Ishikawa, Kinya, Takahashi, Makoto, Obayashi, Masato, Amino, Takeshi, Sato, Nozomu, Sakamoto, Masaki, Fujigasaki, Hiroto, Tsuruta, Fuminori, Dolmetsch, Ricardo, Arai, Takao, Sasaki, Hidenao, Nagashima, Kazuro, Kato, Takeo, Yamada, Mitsunori, Takahashi, Hitoshi, Hashizume, Yoshio, Mizusawa, Hidehiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Medicine Medicine & Public Health Neurosciences Original Paper Pathology
Online-Zugang:	Volltext
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