Intrauterine administration of CDB-2914 (Ulipristal) suppresses the endometrium of rhesus macaques

Abstract Background Ulipristal (UPA; CDB-2914) is a progesterone receptor modulator with contraceptive potential. To test its effects when delivered by an intrauterine system (IUS), we prepared control and UPA-filled IUS and evaluated their effects in rhesus macaques. Study Design Short lengths of S...

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Veröffentlicht in:	Contraception (Stoneham) 2010-04, Vol.81 (4), p.336-342
Hauptverfasser:	Brenner, Robert M, Slayden, Ov D, Nath, Anita, Tsong, Y.Y, Sitruk-Ware, Regine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrophy - chemically induced Atrophy - pathology Biological and medical sciences CDB-2914 Contraceptive Agents, Female - administration & dosage Contraceptive Agents, Female - adverse effects Endometrium Endometrium - drug effects Endometrium - pathology Female Genital system. Reproduction Intrauterine Intrauterine Devices Macaca mulatta Medical sciences Menstruation - drug effects Norpregnadienes - administration & dosage Norpregnadienes - adverse effects Obstetrics and Gynecology Pharmacology. Drug treatments Receptors, Androgen - metabolism Rhesus macaque Ulipristal Uterus
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