early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication

Autophagy is a catabolic process by which cells remove long-lived proteins and damaged organelles for recycling. Viral infections may also induce autophagic response. Here we show that hepatitis B virus (HBV), a pathogen that chronically infects [almost equal to]350 million people globally, can enha...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-03, Vol.107 (9), p.4383-4388
Hauptverfasser:	Sir, Donna, Tian, Yongjun, Chen, Wen-ling, Ann, David K, Yen, Tien-Sze Benedict, Ou, Jing-hsiung James
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Base Sequence Binding sites Biological Sciences Blotting, Northern Blotting, Southern Cell culture Cell lines Cells, Cultured Deoxyribonucleic acid DNA DNA replication DNA, Viral - biosynthesis Enzyme Activation Genomes Hep G2 cells Hepatitis Hepatitis B Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - physiology Hepatocytes Infections Kinases Liver cells Mice Phosphatidylinositol 3-Kinases - metabolism Proteins RNA RNA, Small Interfering Small interfering RNA Virus Replication
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