Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae
A systematic functional analysis across much of the conventional Anopheles gambiae odorant receptor (AgOR) repertoire was carried out in Xenopus oocytes using two-electrode, voltage-clamp electrophysiology. The resulting data indicate that each AgOR manifests a distinct odor-response profile and tun...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2010-03, Vol.107 (9), p.4418-4423 |
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| creator | Wang, Guirong Carey, Allison F Carlson, John R Zwiebel, Laurence J |
| description | A systematic functional analysis across much of the conventional Anopheles gambiae odorant receptor (AgOR) repertoire was carried out in Xenopus oocytes using two-electrode, voltage-clamp electrophysiology. The resulting data indicate that each AgOR manifests a distinct odor-response profile and tuning breadth. The large diversity of tuning responses ranges from AgORs that are responsive to a single or small number of odorants (specialists) to more broadly tuned receptors (generalists). Several AgORs were identified that respond robustly to a range of human volatiles that may play a critical role in anopheline host selection. AgOR responses were analyzed further by constructing a multidimensional odor space representing the relationships between odorants and AgOR responses. Within this space, the distance between odorants is related to both chemical class and concentration and may correlate with olfactory discrimination. This study provides a comprehensive overview of olfactory coding mechanisms of An. gambiae that ultimately may aid in fostering the design and development of olfactory-based strategies for reducing the transmission of malaria and other mosquito-borne diseases. |
| doi_str_mv | 10.1073/pnas.0913392107 |
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This study provides a comprehensive overview of olfactory coding mechanisms of An. gambiae that ultimately may aid in fostering the design and development of olfactory-based strategies for reducing the transmission of malaria and other mosquito-borne diseases.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0913392107</identifier><identifier>PMID: 20160092</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Animals ; Anopheles - genetics ; Anopheles - parasitology ; Anopheles - physiology ; Anopheles gambiae ; Biological Sciences ; chemoreceptors ; Drosophila ; Electrodes ; electrophysiology ; Heptanoic acids ; humans ; Insect Vectors ; Malaria ; Malaria - transmission ; Mosquitoes ; Mosquitos ; Neurons ; neurophysiology ; odor compounds ; Odorant receptors ; Odorants ; Odors ; Oocytes ; Receptors ; Receptors, Odorant - genetics ; smell ; Studies ; volatile compounds ; Xenopus</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2010-03, Vol.107 (9), p.4418-4423</ispartof><rights>Copyright National Academy of Sciences Mar 2, 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-44afe0699584383ed45fd8f2d8354aa63f425f9ab7925e41f99c018f5b7febec3</citedby><cites>FETCH-LOGICAL-c520t-44afe0699584383ed45fd8f2d8354aa63f425f9ab7925e41f99c018f5b7febec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/107/9.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40537139$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40537139$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20160092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Guirong</creatorcontrib><creatorcontrib>Carey, Allison F</creatorcontrib><creatorcontrib>Carlson, John R</creatorcontrib><creatorcontrib>Zwiebel, Laurence J</creatorcontrib><title>Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>A systematic functional analysis across much of the conventional Anopheles gambiae odorant receptor (AgOR) repertoire was carried out in Xenopus oocytes using two-electrode, voltage-clamp electrophysiology. The resulting data indicate that each AgOR manifests a distinct odor-response profile and tuning breadth. The large diversity of tuning responses ranges from AgORs that are responsive to a single or small number of odorants (specialists) to more broadly tuned receptors (generalists). Several AgORs were identified that respond robustly to a range of human volatiles that may play a critical role in anopheline host selection. AgOR responses were analyzed further by constructing a multidimensional odor space representing the relationships between odorants and AgOR responses. Within this space, the distance between odorants is related to both chemical class and concentration and may correlate with olfactory discrimination. This study provides a comprehensive overview of olfactory coding mechanisms of An. gambiae that ultimately may aid in fostering the design and development of olfactory-based strategies for reducing the transmission of malaria and other mosquito-borne diseases.</description><subject>Animals</subject><subject>Anopheles - genetics</subject><subject>Anopheles - parasitology</subject><subject>Anopheles - physiology</subject><subject>Anopheles gambiae</subject><subject>Biological Sciences</subject><subject>chemoreceptors</subject><subject>Drosophila</subject><subject>Electrodes</subject><subject>electrophysiology</subject><subject>Heptanoic acids</subject><subject>humans</subject><subject>Insect Vectors</subject><subject>Malaria</subject><subject>Malaria - transmission</subject><subject>Mosquitoes</subject><subject>Mosquitos</subject><subject>Neurons</subject><subject>neurophysiology</subject><subject>odor compounds</subject><subject>Odorant receptors</subject><subject>Odorants</subject><subject>Odors</subject><subject>Oocytes</subject><subject>Receptors</subject><subject>Receptors, Odorant - genetics</subject><subject>smell</subject><subject>Studies</subject><subject>volatile compounds</subject><subject>Xenopus</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EokvhzAmwuHBKO_bYiX1Bqiq-pKIeoGfLSexdr5J4ayeV-O_xasu2cOFkjd9vnmbmEfKawRmDBs93k81noBmi5uXjCVmxUlW10PCUrAB4UynBxQl5kfMWALRU8JyccGB1KfiKXH-Pg-uWwSba2hwyjZ7GPibaxT5MaxomOm8cHW0hgqV3rpuLOMZ8u4Q50osp7jZucJmu7dgG616SZ94O2b26f0_JzedPPy-_VlfXX75dXlxVneQwV0JY76DWZR6BCl0vpO-V571CKayt0QsuvbZto7l0gnmtO2DKy7bxrnUdnpKPB9_d0o6u79w0JzuYXQqjTb9MtMH8rUxhY9bxznAlgHFZDD7cG6R4u7g8mzHkzg2DnVxcsmlEDapmGv9PIjbAAOtCvv-H3MYlTeUOplxcIEq2h84PUJdizsn549AMzD5Usw_VPIRaOt4-3vXI_0nxEbDvfLBrjDZCMFWANwdgm0t8R0KAxIahLvq7g-5tNHadQjY3P4o9lpszUBzxN5ZIunE</recordid><startdate>20100302</startdate><enddate>20100302</enddate><creator>Wang, Guirong</creator><creator>Carey, Allison F</creator><creator>Carlson, John R</creator><creator>Zwiebel, Laurence J</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>5PM</scope></search><sort><creationdate>20100302</creationdate><title>Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae</title><author>Wang, Guirong ; Carey, Allison F ; Carlson, John R ; Zwiebel, Laurence J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-44afe0699584383ed45fd8f2d8354aa63f425f9ab7925e41f99c018f5b7febec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Anopheles - genetics</topic><topic>Anopheles - parasitology</topic><topic>Anopheles - physiology</topic><topic>Anopheles gambiae</topic><topic>Biological Sciences</topic><topic>chemoreceptors</topic><topic>Drosophila</topic><topic>Electrodes</topic><topic>electrophysiology</topic><topic>Heptanoic acids</topic><topic>humans</topic><topic>Insect Vectors</topic><topic>Malaria</topic><topic>Malaria - transmission</topic><topic>Mosquitoes</topic><topic>Mosquitos</topic><topic>Neurons</topic><topic>neurophysiology</topic><topic>odor compounds</topic><topic>Odorant receptors</topic><topic>Odorants</topic><topic>Odors</topic><topic>Oocytes</topic><topic>Receptors</topic><topic>Receptors, Odorant - genetics</topic><topic>smell</topic><topic>Studies</topic><topic>volatile compounds</topic><topic>Xenopus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Guirong</creatorcontrib><creatorcontrib>Carey, Allison F</creatorcontrib><creatorcontrib>Carlson, John R</creatorcontrib><creatorcontrib>Zwiebel, Laurence J</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Guirong</au><au>Carey, Allison F</au><au>Carlson, John R</au><au>Zwiebel, Laurence J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2010-03-02</date><risdate>2010</risdate><volume>107</volume><issue>9</issue><spage>4418</spage><epage>4423</epage><pages>4418-4423</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>A systematic functional analysis across much of the conventional Anopheles gambiae odorant receptor (AgOR) repertoire was carried out in Xenopus oocytes using two-electrode, voltage-clamp electrophysiology. 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| subjects | Animals Anopheles - genetics Anopheles - parasitology Anopheles - physiology Anopheles gambiae Biological Sciences chemoreceptors Drosophila Electrodes electrophysiology Heptanoic acids humans Insect Vectors Malaria Malaria - transmission Mosquitoes Mosquitos Neurons neurophysiology odor compounds Odorant receptors Odorants Odors Oocytes Receptors Receptors, Odorant - genetics smell Studies volatile compounds Xenopus |
| title | Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae |
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