Host Determinants of HIV-1 Control in African Americans

We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n=515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstr...

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Veröffentlicht in:	The Journal of infectious diseases 2010-04, Vol.201 (8), p.1141-1149
Hauptverfasser:	Pelak, Kimberly, Goldstein, David B., Walley, Nicole M., Fellay, Jacques, Ge, Dongliang, Shianna, Kevin V., Gumbs, Curtis, Gao, Xiaojiang, Maia, Jessica M., Cronin, Kenneth D., Hussain, Shehnaz K., Carrington, Mary, Michael, Nelson L., Weintrob, Amy C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult African Americans AIDS Alleles Ancestry Biological and medical sciences Black or African American - genetics Disease Progression DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology Fundamental and applied biological sciences. Psychology Gene frequency Genome-Wide Association Study Genotype HIV HIV 1 HIV Infections - genetics HIV Infections - immunology HIV Infections - virology HIV-1 - immunology HIV/AIDS HLA B antigens HLA-B Antigens - genetics HLA-B Antigens - immunology HLA-C Antigens - genetics HLA-C Antigens - immunology Human immunodeficiency virus 1 Humans Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Phenotype Polymorphism, Single Nucleotide - genetics Statistical significance Viral load Viral Load - genetics Virology Young Adult
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