Host Determinants of HIV-1 Control in African Americans
We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n=515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstr...
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| Veröffentlicht in: | The Journal of infectious diseases 2010-04, Vol.201 (8), p.1141-1149 |
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| creator | Pelak, Kimberly Goldstein, David B. Walley, Nicole M. Fellay, Jacques Ge, Dongliang Shianna, Kevin V. Gumbs, Curtis Gao, Xiaojiang Maia, Jessica M. Cronin, Kenneth D. Hussain, Shehnaz K. Carrington, Mary Michael, Nelson L. Weintrob, Amy C. |
| description | We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n=515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P=5.6×10−10). These analyses therefore confirm a member of the HLAB* 57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701. |
| doi_str_mv | 10.1086/651382 |
| format | Article |
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We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P=5.6×10−10). These analyses therefore confirm a member of the HLAB* 57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.</description><identifier>ISSN: 0022-1899</identifier><identifier>ISSN: 1537-6613</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/651382</identifier><identifier>PMID: 20205591</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Oxford: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; African Americans ; AIDS ; Alleles ; Ancestry ; Biological and medical sciences ; Black or African American - genetics ; Disease Progression ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - immunology ; Fundamental and applied biological sciences. Psychology ; Gene frequency ; Genome-Wide Association Study ; Genotype ; HIV ; HIV 1 ; HIV Infections - genetics ; HIV Infections - immunology ; HIV Infections - virology ; HIV-1 - immunology ; HIV/AIDS ; HLA B antigens ; HLA-B Antigens - genetics ; HLA-B Antigens - immunology ; HLA-C Antigens - genetics ; HLA-C Antigens - immunology ; Human immunodeficiency virus 1 ; Humans ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Phenotype ; Polymorphism, Single Nucleotide - genetics ; Statistical significance ; Viral load ; Viral Load - genetics ; Virology ; Young Adult</subject><ispartof>The Journal of infectious diseases, 2010-04, Vol.201 (8), p.1141-1149</ispartof><rights>2010 Infectious Diseases Society of America</rights><rights>2010 by the Infectious Diseases Society of America 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-adaf1a38796289a91b3826706d541fe047db850397eba542d5bcf821aed42e383</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40599262$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40599262$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22541490$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20205591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pelak, Kimberly</creatorcontrib><creatorcontrib>Goldstein, David B.</creatorcontrib><creatorcontrib>Walley, Nicole M.</creatorcontrib><creatorcontrib>Fellay, Jacques</creatorcontrib><creatorcontrib>Ge, Dongliang</creatorcontrib><creatorcontrib>Shianna, Kevin V.</creatorcontrib><creatorcontrib>Gumbs, Curtis</creatorcontrib><creatorcontrib>Gao, Xiaojiang</creatorcontrib><creatorcontrib>Maia, Jessica M.</creatorcontrib><creatorcontrib>Cronin, Kenneth D.</creatorcontrib><creatorcontrib>Hussain, Shehnaz K.</creatorcontrib><creatorcontrib>Carrington, Mary</creatorcontrib><creatorcontrib>Michael, Nelson L.</creatorcontrib><creatorcontrib>Weintrob, Amy C.</creatorcontrib><creatorcontrib>Infectious Disease Clinical Research Program HIV Working Group, on behalf of the National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI)</creatorcontrib><creatorcontrib>Infectious Disease Clinical Research Program HIV Working Group</creatorcontrib><creatorcontrib>National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI)</creatorcontrib><title>Host Determinants of HIV-1 Control in African Americans</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n=515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P=5.6×10−10). These analyses therefore confirm a member of the HLAB* 57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.</description><subject>Adolescent</subject><subject>Adult</subject><subject>African Americans</subject><subject>AIDS</subject><subject>Alleles</subject><subject>Ancestry</subject><subject>Biological and medical sciences</subject><subject>Black or African American - genetics</subject><subject>Disease Progression</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene frequency</subject><subject>Genome-Wide Association Study</subject><subject>Genotype</subject><subject>HIV</subject><subject>HIV 1</subject><subject>HIV Infections - genetics</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - immunology</subject><subject>HIV/AIDS</subject><subject>HLA B antigens</subject><subject>HLA-B Antigens - genetics</subject><subject>HLA-B Antigens - immunology</subject><subject>HLA-C Antigens - genetics</subject><subject>HLA-C Antigens - immunology</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Phenotype</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Statistical significance</subject><subject>Viral load</subject><subject>Viral Load - genetics</subject><subject>Virology</subject><subject>Young Adult</subject><issn>0022-1899</issn><issn>1537-6613</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EokuBbwAKB-AUGP-3L0jVAk2lSlxKhbhYk8QBlyTe2lkE355ssyxwQOppRno_vXn2I-QxhVcUjHqtJOWG3SErKrkulaL8LlkBMFZSY-0ReZDzFQAIrvR9csSAgZSWroiuYp6Kt37yaQgjjlMuYldUZ5clLdZxnFLsizAWJ10KDc5z8DdLfkjuddhn_2g_j8nH9-8u1lV5_uH0bH1yXjaK0qnEFjuK3GirmLFoaT2nVBpUKwXtPAjd1kYCt9rXKAVrZd10hlH0rWCeG35M3iy-m209-LbxcyTs3SaFAdNPFzG4f5UxfHVf4nfHDDdWwGzwcm-Q4vXW58kNITe-73H0cZudlpZTEFbfghRyjmhv4cm5EtzyneeLhWxSzDn57pCcgtsV55biZvDp3-88YL-bmoHnewBzg32XcGxC_sOx-UPFTbZnCxe3m_8fe7IwV3mK6UAJkNYytdPLRQ958j8OOqZvTmmupas-fXanF5Xh7JI64L8AGgu_nw</recordid><startdate>20100415</startdate><enddate>20100415</enddate><creator>Pelak, Kimberly</creator><creator>Goldstein, David B.</creator><creator>Walley, Nicole M.</creator><creator>Fellay, Jacques</creator><creator>Ge, Dongliang</creator><creator>Shianna, Kevin V.</creator><creator>Gumbs, Curtis</creator><creator>Gao, Xiaojiang</creator><creator>Maia, Jessica M.</creator><creator>Cronin, Kenneth D.</creator><creator>Hussain, Shehnaz K.</creator><creator>Carrington, Mary</creator><creator>Michael, Nelson L.</creator><creator>Weintrob, Amy C.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7T5</scope><scope>7U2</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20100415</creationdate><title>Host Determinants of HIV-1 Control in African Americans</title><author>Pelak, Kimberly ; Goldstein, David B. ; Walley, Nicole M. ; Fellay, Jacques ; Ge, Dongliang ; Shianna, Kevin V. ; Gumbs, Curtis ; Gao, Xiaojiang ; Maia, Jessica M. ; Cronin, Kenneth D. ; Hussain, Shehnaz K. ; Carrington, Mary ; Michael, Nelson L. ; Weintrob, Amy C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c611t-adaf1a38796289a91b3826706d541fe047db850397eba542d5bcf821aed42e383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>African Americans</topic><topic>AIDS</topic><topic>Alleles</topic><topic>Ancestry</topic><topic>Biological and medical sciences</topic><topic>Black or African American - genetics</topic><topic>Disease Progression</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - immunology</topic><topic>Fundamental and applied biological sciences. 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We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P=5.6×10−10). These analyses therefore confirm a member of the HLAB* 57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.</abstract><cop>Oxford</cop><pub>The University of Chicago Press</pub><pmid>20205591</pmid><doi>10.1086/651382</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult African Americans AIDS Alleles Ancestry Biological and medical sciences Black or African American - genetics Disease Progression DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology Fundamental and applied biological sciences. Psychology Gene frequency Genome-Wide Association Study Genotype HIV HIV 1 HIV Infections - genetics HIV Infections - immunology HIV Infections - virology HIV-1 - immunology HIV/AIDS HLA B antigens HLA-B Antigens - genetics HLA-B Antigens - immunology HLA-C Antigens - genetics HLA-C Antigens - immunology Human immunodeficiency virus 1 Humans Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Phenotype Polymorphism, Single Nucleotide - genetics Statistical significance Viral load Viral Load - genetics Virology Young Adult |
| title | Host Determinants of HIV-1 Control in African Americans |
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