The Role of Tissue Factor and Factor VIIa in Hemostasis

Tissue factor (TF) is a transmembrane receptor for Factor VII/VIIa (FVII/VIIa). It is constitutively expressed by cells surrounding blood vessels. The endothelium physically separates this potent “activator” from its circulating ligand FVII/FVIIa and prevents inappropriate activation of the clotting...

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Veröffentlicht in:	Anesthesia and analgesia 2009-05, Vol.108 (5), p.1447-1452
1. Verfasser:	Mackman, Nigel
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Cell-Derived Microparticles - metabolism Endothelium, Vascular - metabolism Factor VIIa - adverse effects Factor VIIa - metabolism Factor VIIa - therapeutic use Hemophilia A - blood Hemophilia A - drug therapy Hemostasis - drug effects Hemostatics - adverse effects Hemostatics - therapeutic use Humans Medical sciences Recombinant Proteins - adverse effects Recombinant Proteins - therapeutic use Thromboplastin - metabolism Thrombosis - chemically induced
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