Fibrosis and cancer: Do myofibroblasts come also from epithelial cells via EMT?

Myofibroblasts produce and modify the extracellular matrix (ECM), secrete angiogenic and pro‐inflammatory factors, and stimulate epithelial cell proliferation and invasion. Myofibroblasts are normally induced transiently during wound healing, but inappropriate induction of myofibroblasts causes orga...

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Veröffentlicht in:	Journal of cellular biochemistry 2007-07, Vol.101 (4), p.830-839
Hauptverfasser:	Radisky, Derek C., Kenny, Paraic A., Bissell, Mina J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Transformation, Neoplastic Epithelial Cells - metabolism Epithelial Cells - pathology epithelial-mesenchymal transition extracellular matrix Extracellular Matrix - metabolism Fibrosis Humans matrix metalloproteinases Matrix Metalloproteinases - metabolism Mesoderm - metabolism Mesoderm - pathology Neoplasms - metabolism Neoplasms - pathology tumor microenvironment
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