Activation of the AMP-activated protein kinase–p38 MAP kinase pathway mediates apoptosis induced by conjugated linoleic acid in p53-mutant mouse mammary tumor cells

Conjugated linoleic acid (CLA) inhibits tumorigenesis and tumor growth in most model systems, an effect mediated in part by its pro-apoptotic activity. We previously showed that trans-10,cis-12 CLA induced apoptosis of p53-mutant TM4t mouse mammary tumor cells through both mitochondrial and endoplas...

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Veröffentlicht in:	Cellular signalling 2010-04, Vol.22 (4), p.590-599
Hauptverfasser:	Hsu, Yung-Chung, Meng, Xiaojing, Ou, Lihui, Ip, Margot M.
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP kinase AMP-Activated Protein Kinases - metabolism Animals Apoptosis Cell Line, Tumor Conjugated linoleic acid Enzyme Activation Female Linoleic Acids, Conjugated - metabolism Mammary Neoplasms, Animal - genetics Mammary Neoplasms, Animal - metabolism Mammary tumor cells Mechanistic Target of Rapamycin Complex 1 Mice mTOR Multiprotein Complexes Mutation p38 MAP kinase p38 Mitogen-Activated Protein Kinases - metabolism Proteins TOR Serine-Threonine Kinases Transcription Factors - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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