IgG-single chain Fv fusion protein therapeutic for alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey

Monoclonal antibodies (MAb) directed against the Abeta amyloid peptide of Alzheimer's disease (AD) are potential new therapies for AD, since these antibodies disaggregate brain amyloid plaque. However, the MAb is not transported across the blood-brain barrier (BBB). To enable BBB transport, a s...

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Veröffentlicht in:	Biotechnology and bioengineering 2010-02, Vol.105 (3), p.627-635
Hauptverfasser:	Boado, Ruben J, Lu, Jeff Zhiqiang, Hui, Eric Ka-Wai, Pardridge, William M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer's disease Amyloid beta-Peptides - antagonists & inhibitors Animals Antibodies, Monoclonal - genetics Antibodies, Monoclonal - metabolism Biological and medical sciences Biotechnology blood-brain barrier Brain Brain - immunology CHO Cells Cricetinae Cricetulus delivery systems Fundamental and applied biological sciences. Psychology Gene Expression Immunoglobulin Fragments - genetics Immunoglobulin Fragments - metabolism Immunoglobulin G - genetics Immunoglobulin G - metabolism Immunologic Factors - genetics Immunologic Factors - pharmacokinetics Insulin Insulin - immunology Iodine Radioisotopes - analysis Macaca mulatta Monoclonal antibodies monoclonal antibody Peptides Primates Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - pharmacokinetics Rodents Staining and Labeling Therapy Transfection
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