Anacardic acid inhibits estrogen receptor alpha-DNA binding and reduces target gene transcription and breast cancer cell proliferation

Anacardic acid (AnAc; 2-hydroxy-6-alkylbenzoic acid) is a dietary and medicinal phytochemical with established anticancer activity in cell and animal models. The mechanisms by which AnAc inhibits cancer cell proliferation remain undefined. AnAc 24:1(omega5) was purified from geranium (Pelargonium x...

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Veröffentlicht in:	Molecular cancer therapeutics 2010-03, Vol.9 (3), p.594-605
Hauptverfasser:	Schultz, David J, Wickramasinghe, Nalinie S, Ivanova, Margarita M, Isaacs, Susan M, Dougherty, Susan M, Imbert-Fernandez, Yoannis, Cunningham, Albert R, Chen, Chunyuan, Klinge, Carolyn M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anacardic Acids - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Apoptosis - genetics Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Proliferation - drug effects DNA - drug effects DNA - metabolism Down-Regulation - drug effects Down-Regulation - genetics Estrogen Receptor alpha - antagonists & inhibitors Estrogen Receptor alpha - metabolism Female Gene Expression Regulation, Neoplastic - drug effects Genes, Reporter - drug effects Humans Protein Binding - drug effects Transcription, Genetic - drug effects Transcriptional Activation - drug effects Transfection Tumor Cells, Cultured
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