Analysis of lidocaine interactions with serum proteins using high-performance affinity chromatography

High-performance affinity chromatography was used to study binding by the drug lidocaine to human serum albumin (HSA) and α 1-acid glycoprotein (AGP). AGP had strong binding to lidocaine, with an association equilibrium constant ( K a) of 1.1–1.7 × 10 5 M −1 at 37 °C and pH 7.4. Lidocaine had weak t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2010-03, Vol.878 (7), p.705-708
Hauptverfasser:	Soman, Sony, Yoo, Michelle J., Jang, Yoon Jeong, Hage, David S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Analysis Analytical, structural and metabolic biochemistry Binding Binding, Competitive Biological and medical sciences Chemical equilibrium Chromatography Chromatography, Affinity - methods Circulation Drugs Fundamental and applied biological sciences. Psychology General pharmacology High-performance affinity chromatography Human Human serum albumin Humans Kinetics Lidocaine Lidocaine - chemistry Lidocaine - metabolism Linear Models Medical sciences Orosomucoid - chemistry Orosomucoid - metabolism Pharmacology. Drug treatments Propranolol - chemistry Protein Binding Serum Albumin - chemistry Serum Albumin - metabolism Serum proteins α 1-Acid glycoprotein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!