Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

Epidemiological studies indicate that overweight and obesity are associated with increased cancer risk. To study how obesity augments cancer risk and development, we focused on hepatocellular carcinoma (HCC), the common form of liver cancer whose occurrence and progression are the most strongly affe...

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Veröffentlicht in:	Cell 2010-01, Vol.140 (2), p.197-208
Hauptverfasser:	Park, Eek Joong, Lee, Jun Hee, Yu, Guann-Yi, He, Guobin, Ali, Syed Raza, Holzer, Ryan G., Österreicher, Christoph H., Takahashi, Hiroyuki, Karin, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body weight Carcinoma, Hepatocellular - chemically induced Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - immunology Cell Proliferation CELLBIO Diethylnitrosamine Extracellular Signal-Regulated MAP Kinases - metabolism Female Hepatitis - etiology Hepatitis - immunology Hepatocellular carcinoma HUMDISEASE Inflammation Interleukin 6 Interleukin-6 - immunology Liver cancer Liver Neoplasms - chemically induced Liver Neoplasms - etiology Liver Neoplasms - immunology Male Mice Obesity Obesity - complications Obesity - immunology Promoters SIGNALING Stat3 protein STAT3 Transcription Factor - metabolism Transcription factors Tumor necrosis factor Tumor Necrosis Factor-alpha - immunology Tumorigenesis
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