Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway

Aims On the basis of our previous reports that cardioprotection induced by ischaemic preconditioning induces autophagy and that resveratrol, a polyphenolic antioxidant present in grapes and red wine induces preconditioning-like effects, we sought to determine if resveratrol could induce autophagy. M...

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Veröffentlicht in:	Cardiovascular research 2010-04, Vol.86 (1), p.103-112
Hauptverfasser:	Gurusamy, Narasimman, Lekli, Istvan, Mukherjee, Subhendu, Ray, Diptarka, Ahsan, Md. Kaimul, Gherghiceanu, Mihaela, Popescu, Lawrence M., Das, Dipak K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Autophagy Autophagy - drug effects Autophagy - physiology Biological and medical sciences Cardiology. Vascular system Cardioprotection Cardiotonic Agents - pharmacology Carrier Proteins - metabolism Cell Line Cell survival Cell Survival - drug effects Dose-Response Relationship, Drug Intracellular Signaling Peptides and Proteins - metabolism Male Medical sciences mTOR Myoblasts, Cardiac - cytology Myoblasts, Cardiac - drug effects Myoblasts, Cardiac - metabolism Myocardium - cytology Original Phosphorylation - drug effects Protein-Serine-Threonine Kinases - metabolism Rapamycin-Insensitive Companion of mTOR Protein Rats Rats, Sprague-Dawley Resveratrol Rictor Stilbenes - pharmacology TOR Serine-Threonine Kinases Transcription Factors - metabolism
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