The Dual Role of Zonula Occludens (ZO) Proteins
ZO (zonula occludens) proteins are scaffolding proteins providing the structural basis for the assembly of multiprotein complexes at the cytoplasmic surface of intercellular junctions. In addition, they provide a link between the integral membrane proteins and the filamentous cytoskeleton. ZO protei...
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description | ZO (zonula occludens) proteins are scaffolding proteins providing the structural basis for the assembly of multiprotein complexes at the cytoplasmic surface of intercellular junctions. In addition, they provide a link between the integral membrane proteins and the filamentous cytoskeleton. ZO proteins belong to the large family of membrane-associated guanylate kinase (MAGUK)-like proteins comprising a number of subfamilies based on domain content and sequence similarity. Besides their structural function at cell-cell contacts, ZO proteins appear to participate in the regulation of cell growth and proliferation. Detailed molecular studies have shown that ZO proteins exhibit conserved functional nuclear localization and nuclear export motifs within their amino acid sequence. Further, ZO proteins interact with dual residency proteins localizing to the plasma membrane and the nucleus. Although the nuclear targeting of ZO proteins has well been described, many questions concerning the biological significance of this process have remained open. This review focuses on the dual role of ZO proteins, being indispensable structural components at the junctional site and functioning in signal transduction pathways related to gene expression and cell behavior. |
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C. ; Bauer, H.</creator><contributor>McCann, Amanda</contributor><creatorcontrib>Lametschwandtner, A. ; Zweimueller-Mayer, J. ; Steinbacher, P. ; Bauer, H. C. ; Bauer, H. ; McCann, Amanda</creatorcontrib><description>ZO (zonula occludens) proteins are scaffolding proteins providing the structural basis for the assembly of multiprotein complexes at the cytoplasmic surface of intercellular junctions. In addition, they provide a link between the integral membrane proteins and the filamentous cytoskeleton. ZO proteins belong to the large family of membrane-associated guanylate kinase (MAGUK)-like proteins comprising a number of subfamilies based on domain content and sequence similarity. Besides their structural function at cell-cell contacts, ZO proteins appear to participate in the regulation of cell growth and proliferation. Detailed molecular studies have shown that ZO proteins exhibit conserved functional nuclear localization and nuclear export motifs within their amino acid sequence. Further, ZO proteins interact with dual residency proteins localizing to the plasma membrane and the nucleus. Although the nuclear targeting of ZO proteins has well been described, many questions concerning the biological significance of this process have remained open. This review focuses on the dual role of ZO proteins, being indispensable structural components at the junctional site and functioning in signal transduction pathways related to gene expression and cell behavior.</description><identifier>ISSN: 1110-7243</identifier><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 1110-7251</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2010/402593</identifier><identifier>PMID: 20224657</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Adapter proteins ; Adenoviruses ; Animals ; Biomedical research ; Cell adhesion & migration ; Cell cycle ; Cell Enlargement ; Cell growth ; Cell Nucleus - physiology ; Cell Proliferation ; Epithelial Cells - physiology ; Humans ; Insects ; Kinases ; Membrane Proteins - metabolism ; Review ; Signal transduction ; Tight Junctions - physiology</subject><ispartof>BioMed research international, 2010-01, Vol.2010 (2010), p.1-11</ispartof><rights>Copyright © 2010</rights><rights>Copyright © 2010 H. Bauer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2010 H. Bauer et al. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c594t-ce624e65077c9a40ff31d3f01756d8695d0cde930802e8420297f061915974d83</citedby><cites>FETCH-LOGICAL-c594t-ce624e65077c9a40ff31d3f01756d8695d0cde930802e8420297f061915974d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836178/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836178/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20224657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>McCann, Amanda</contributor><creatorcontrib>Lametschwandtner, A.</creatorcontrib><creatorcontrib>Zweimueller-Mayer, J.</creatorcontrib><creatorcontrib>Steinbacher, P.</creatorcontrib><creatorcontrib>Bauer, H. C.</creatorcontrib><creatorcontrib>Bauer, H.</creatorcontrib><title>The Dual Role of Zonula Occludens (ZO) Proteins</title><title>BioMed research international</title><addtitle>J Biomed Biotechnol</addtitle><description>ZO (zonula occludens) proteins are scaffolding proteins providing the structural basis for the assembly of multiprotein complexes at the cytoplasmic surface of intercellular junctions. In addition, they provide a link between the integral membrane proteins and the filamentous cytoskeleton. ZO proteins belong to the large family of membrane-associated guanylate kinase (MAGUK)-like proteins comprising a number of subfamilies based on domain content and sequence similarity. Besides their structural function at cell-cell contacts, ZO proteins appear to participate in the regulation of cell growth and proliferation. Detailed molecular studies have shown that ZO proteins exhibit conserved functional nuclear localization and nuclear export motifs within their amino acid sequence. Further, ZO proteins interact with dual residency proteins localizing to the plasma membrane and the nucleus. Although the nuclear targeting of ZO proteins has well been described, many questions concerning the biological significance of this process have remained open. This review focuses on the dual role of ZO proteins, being indispensable structural components at the junctional site and functioning in signal transduction pathways related to gene expression and cell behavior.</description><subject>Adapter proteins</subject><subject>Adenoviruses</subject><subject>Animals</subject><subject>Biomedical research</subject><subject>Cell adhesion & migration</subject><subject>Cell cycle</subject><subject>Cell Enlargement</subject><subject>Cell growth</subject><subject>Cell Nucleus - physiology</subject><subject>Cell Proliferation</subject><subject>Epithelial Cells - physiology</subject><subject>Humans</subject><subject>Insects</subject><subject>Kinases</subject><subject>Membrane Proteins - metabolism</subject><subject>Review</subject><subject>Signal transduction</subject><subject>Tight Junctions - physiology</subject><issn>1110-7243</issn><issn>2314-6133</issn><issn>1110-7251</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqN0c-LEzEUB_Agiu1WT56Vwcu6yti8_JxchKWuq1CoSL30EmLmjZ1lOulOZpT97zdlalEvekogH768ly8hz4C-BZByzijQuaBMGv6ATAGA5ppJeHi6Cz4hZzHeUAq6UOYxmTDKmFBST8l8vcXs_eCa7EtoMAtVtgnt0Lhs5X0zlNjG7NVmdZF97kKPdRufkEeVayI-PZ4z8vXD1XrxMV-urj8tLpe5l0b0uUfFBCpJtfbGCVpVHEpepQGkKtMMsqS-RMNpQRkWIs1jdEUVGJBGi7LgM_JuzN0P33ZYemz7zjV239U7193Z4Gr750tbb-338MOygqu0Zgo4PwZ04XbA2NtdHT02jWsxDNFqIVQB9H8k51yA0CrJl3_JmzB0bfoHW0gFShsBCb0Zke9CjB1Wp6GB2kNh9lCYHQtL-sXve57sr4YSeD2Cbd2W7mf9j7TnI8ZEsHInLJRhIPk97LuitA</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Lametschwandtner, A.</creator><creator>Zweimueller-Mayer, J.</creator><creator>Steinbacher, P.</creator><creator>Bauer, H. 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C.</au><au>Bauer, H.</au><au>McCann, Amanda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Dual Role of Zonula Occludens (ZO) Proteins</atitle><jtitle>BioMed research international</jtitle><addtitle>J Biomed Biotechnol</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>2010</volume><issue>2010</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>1110-7243</issn><issn>2314-6133</issn><eissn>1110-7251</eissn><eissn>2314-6141</eissn><abstract>ZO (zonula occludens) proteins are scaffolding proteins providing the structural basis for the assembly of multiprotein complexes at the cytoplasmic surface of intercellular junctions. In addition, they provide a link between the integral membrane proteins and the filamentous cytoskeleton. ZO proteins belong to the large family of membrane-associated guanylate kinase (MAGUK)-like proteins comprising a number of subfamilies based on domain content and sequence similarity. Besides their structural function at cell-cell contacts, ZO proteins appear to participate in the regulation of cell growth and proliferation. Detailed molecular studies have shown that ZO proteins exhibit conserved functional nuclear localization and nuclear export motifs within their amino acid sequence. Further, ZO proteins interact with dual residency proteins localizing to the plasma membrane and the nucleus. Although the nuclear targeting of ZO proteins has well been described, many questions concerning the biological significance of this process have remained open. This review focuses on the dual role of ZO proteins, being indispensable structural components at the junctional site and functioning in signal transduction pathways related to gene expression and cell behavior.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>20224657</pmid><doi>10.1155/2010/402593</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adapter proteins Adenoviruses Animals Biomedical research Cell adhesion & migration Cell cycle Cell Enlargement Cell growth Cell Nucleus - physiology Cell Proliferation Epithelial Cells - physiology Humans Insects Kinases Membrane Proteins - metabolism Review Signal transduction Tight Junctions - physiology |
title | The Dual Role of Zonula Occludens (ZO) Proteins |
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