Transplantation of Mesenchymal Stem Cells Overexpressing RANK-Fc or CXCR4 Prevents Bone Loss in Ovariectomized Mice

Osteoporosis is a systemic skeletal disorder characterized by reduced bone mineral density (BMD) and increased risk of fracture. We studied the effects of transplantation of mesenchymal stem cells (MSCs) overexpressing receptor activator of nuclear factor-κB (RANK)-Fc and CXC chemokine receptor-4 (C...

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Veröffentlicht in:	Molecular therapy 2009-11, Vol.17 (11), p.1979-1987
Hauptverfasser:	Cho, Sun Wook, Sun, Hyun Jin, Yang, Jae-Yeon, Jung, Ju Yeon, An, Jee Hyun, Cho, Hwa Young, Choi, Hyung Jin, Kim, Sang Wan, Kim, Seong Yeon, Kim, Dohee, Shin, Chan Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body fat Bone density Bone marrow Chemokines Enzyme-Linked Immunosorbent Assay Female Fractures Gene Expression Internal medicine Medicine Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mesenchymal Stem Cells - physiology Mice Mice, Inbred BALB C Oophorectomy Original Osteoporosis Osteoporosis - prevention & control Ovariectomy Proteins Receptors, CXCR4 - genetics Receptors, CXCR4 - physiology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - physiology Stem cells University colleges
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