Recombinant AAV Serotype and Capsid Mutant Comparison for Pulmonary Gene Transfer of α-1-Antitrypsin Using Invasive and Noninvasive Delivery

Recombinant adeno-associated viral (rAAV) vectors have been widely used in pulmonary gene therapy research. In this study, we evaluated the transduction and expression efficiencies of several AAV serotypes and AAV2 capsid mutants with specific pulmonary targeting ligands in the mouse lung. The nonin...

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Veröffentlicht in:	Molecular therapy 2009-01, Vol.17 (1), p.81-87
Hauptverfasser:	Liqun Wang, Rejean, McLaughlin, Thomas, Cossette, Travis, Tang, Qiushi, Foust, Kevin, Campbell-Thompson, Martha, Martino, Ashley, Cruz, Pedro, Loiler, Scott, Mueller, Christian, Flotte, Terence R
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha 1-Antitrypsin - blood alpha 1-Antitrypsin - genetics Animals Capsid - metabolism Dependovirus - genetics Enzyme-Linked Immunosorbent Assay Gene Transfer Techniques Genetic Vectors - genetics Lung Mice Mice, Inbred C57BL Original Polymerase Chain Reaction
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