Uromodulin Levels Associate with a Common UMOD Variant and Risk for Incident CKD
Common variants in the region of the UMOD gene, which encodes uromodulin (Tamm-Horsfall protein), associate with chronic kidney disease (CKD) and estimated GFR (eGFR). Whether uromodulin levels associate with UMOD variants or with the risk for developing CKD is unknown. We conducted an age- and gend...
Gespeichert in:
| Veröffentlicht in: | Journal of the American Society of Nephrology 2010-02, Vol.21 (2), p.337-344 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 344 |
|---|---|
| container_issue | 2 |
| container_start_page | 337 |
| container_title | Journal of the American Society of Nephrology |
| container_volume | 21 |
| creator | KÖTTGEN, Anna HWANG, Shih-Jen GUDNASON, Vilmundur SHLIPAK, Michael G QIONG YANG CORESH, Josef LEVY, Daniel FOX, Caroline S LARSON, Martin G VAN EYK, Jennifer E QIN FU BENJAMIN, Emelia J DEHGHAN, Abbas GLAZER, Nicole L LINDA KAO, W. H HARRIS, Tamara B |
| description | Common variants in the region of the UMOD gene, which encodes uromodulin (Tamm-Horsfall protein), associate with chronic kidney disease (CKD) and estimated GFR (eGFR). Whether uromodulin levels associate with UMOD variants or with the risk for developing CKD is unknown. We conducted an age- and gender-matched case-control study (n = 200) of incident CKD (eGFR |
| doi_str_mv | 10.1681/ASN.2009070725 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2834540</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733710481</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-3d6854a970f5ebdcd1cfd134d97a694a9beab2451099769f5344670731d082993</originalsourceid><addsrcrecordid>eNpVkUlPBCEQhYnRuF89Gi7GU4-sTXMxmYxrHJeo45UwQCva3YzQo_Hfi3HicoJQH6-q3gNgB6MBLit8MLy7GhCEJBJIEL4E1jGntKCMo-V8R6wsylLQNbCR0jNCmBMhVsEalpJLgfk6uJnE0AY7b3wHx-7NNQkOUwrG697Bd98_QQ1HoW1DByeX10fwQUevux7qzsJbn15gHSI874y3Lr-OLo62wEqtm-S2F-cmmJwc34_OivH16floOC4Mw7IvqC0rzrQUqOZuao3FpraYMiuFLmUuTJ2eEsYxklKUsuaUsTLvSLFFFZGSboLDb93ZfNo6a3L7qBs1i77V8UMF7dX_Suef1GN4U6TK7jCUBfYXAjG8zl3qVeuTcU2jOxfmSQlKRTawwpkcfJMmhpSiq3-6YKS-UlA5BfWbQv6w-3e2X3xhewb2FoBORjd11NnB9MMRQqWgjNBP6QSOYw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733710481</pqid></control><display><type>article</type><title>Uromodulin Levels Associate with a Common UMOD Variant and Risk for Incident CKD</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>KÖTTGEN, Anna ; HWANG, Shih-Jen ; GUDNASON, Vilmundur ; SHLIPAK, Michael G ; QIONG YANG ; CORESH, Josef ; LEVY, Daniel ; FOX, Caroline S ; LARSON, Martin G ; VAN EYK, Jennifer E ; QIN FU ; BENJAMIN, Emelia J ; DEHGHAN, Abbas ; GLAZER, Nicole L ; LINDA KAO, W. H ; HARRIS, Tamara B</creator><creatorcontrib>KÖTTGEN, Anna ; HWANG, Shih-Jen ; GUDNASON, Vilmundur ; SHLIPAK, Michael G ; QIONG YANG ; CORESH, Josef ; LEVY, Daniel ; FOX, Caroline S ; LARSON, Martin G ; VAN EYK, Jennifer E ; QIN FU ; BENJAMIN, Emelia J ; DEHGHAN, Abbas ; GLAZER, Nicole L ; LINDA KAO, W. H ; HARRIS, Tamara B</creatorcontrib><description>Common variants in the region of the UMOD gene, which encodes uromodulin (Tamm-Horsfall protein), associate with chronic kidney disease (CKD) and estimated GFR (eGFR). Whether uromodulin levels associate with UMOD variants or with the risk for developing CKD is unknown. We conducted an age- and gender-matched case-control study (n = 200) of incident CKD (eGFR <60 ml/min per 1.73 m(2)) within the Framingham Heart Study (FHS). Baseline urinary uromodulin concentrations were related to case-control status 9.9 yr later and to genotype at rs4293393. As a replication set, we tested the genotype association with uromodulin concentration in the Atherosclerosis Risk in Communities (ARIC) Study (n = 42). Geometric means of uromodulin concentrations were 51% higher in case than in control subjects (P = 0.016). The adjusted odds ratio of CKD per 1-SD higher concentration of uromodulin was 1.72 (95% confidence interval 1.07 to 2.77; P = 0.03) after accounting for CKD risk factors and baseline eGFR. We observed lower urinary uromodulin concentrations per each copy of the C allele at rs4293393 in both cohorts. In summary, elevated uromodulin concentrations precede the onset of CKD and associate with a common polymorphism in the UMOD region.</description><identifier>ISSN: 1046-6673</identifier><identifier>ISSN: 1533-3450</identifier><identifier>EISSN: 1533-3450</identifier><identifier>DOI: 10.1681/ASN.2009070725</identifier><identifier>PMID: 19959715</identifier><identifier>CODEN: JASNEU</identifier><language>eng</language><publisher>Washington, DC: American Society of Nephrology</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Case-Control Studies ; Chronic Disease ; Clinical Epidemiology ; Female ; Genetic Predisposition to Disease - genetics ; Genotype ; Glomerular Filtration Rate - physiology ; Humans ; Kidney Diseases - genetics ; Kidney Diseases - physiopathology ; Kidney Diseases - urine ; Kidney Diseases, Cystic - genetics ; Kidneys ; Male ; Medical sciences ; Middle Aged ; Molecular Motor Proteins - genetics ; Mucoproteins - genetics ; Mucoproteins - urine ; Myosin Heavy Chains - genetics ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Polymorphism, Single Nucleotide - genetics ; Renal failure ; Risk Factors ; Urinary system involvement in other diseases. Miscellaneous ; Uromodulin</subject><ispartof>Journal of the American Society of Nephrology, 2010-02, Vol.21 (2), p.337-344</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 by the American Society of Nephrology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-3d6854a970f5ebdcd1cfd134d97a694a9beab2451099769f5344670731d082993</citedby><cites>FETCH-LOGICAL-c419t-3d6854a970f5ebdcd1cfd134d97a694a9beab2451099769f5344670731d082993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834540/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834540/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22397342$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19959715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KÖTTGEN, Anna</creatorcontrib><creatorcontrib>HWANG, Shih-Jen</creatorcontrib><creatorcontrib>GUDNASON, Vilmundur</creatorcontrib><creatorcontrib>SHLIPAK, Michael G</creatorcontrib><creatorcontrib>QIONG YANG</creatorcontrib><creatorcontrib>CORESH, Josef</creatorcontrib><creatorcontrib>LEVY, Daniel</creatorcontrib><creatorcontrib>FOX, Caroline S</creatorcontrib><creatorcontrib>LARSON, Martin G</creatorcontrib><creatorcontrib>VAN EYK, Jennifer E</creatorcontrib><creatorcontrib>QIN FU</creatorcontrib><creatorcontrib>BENJAMIN, Emelia J</creatorcontrib><creatorcontrib>DEHGHAN, Abbas</creatorcontrib><creatorcontrib>GLAZER, Nicole L</creatorcontrib><creatorcontrib>LINDA KAO, W. H</creatorcontrib><creatorcontrib>HARRIS, Tamara B</creatorcontrib><title>Uromodulin Levels Associate with a Common UMOD Variant and Risk for Incident CKD</title><title>Journal of the American Society of Nephrology</title><addtitle>J Am Soc Nephrol</addtitle><description>Common variants in the region of the UMOD gene, which encodes uromodulin (Tamm-Horsfall protein), associate with chronic kidney disease (CKD) and estimated GFR (eGFR). Whether uromodulin levels associate with UMOD variants or with the risk for developing CKD is unknown. We conducted an age- and gender-matched case-control study (n = 200) of incident CKD (eGFR <60 ml/min per 1.73 m(2)) within the Framingham Heart Study (FHS). Baseline urinary uromodulin concentrations were related to case-control status 9.9 yr later and to genotype at rs4293393. As a replication set, we tested the genotype association with uromodulin concentration in the Atherosclerosis Risk in Communities (ARIC) Study (n = 42). Geometric means of uromodulin concentrations were 51% higher in case than in control subjects (P = 0.016). The adjusted odds ratio of CKD per 1-SD higher concentration of uromodulin was 1.72 (95% confidence interval 1.07 to 2.77; P = 0.03) after accounting for CKD risk factors and baseline eGFR. We observed lower urinary uromodulin concentrations per each copy of the C allele at rs4293393 in both cohorts. In summary, elevated uromodulin concentrations precede the onset of CKD and associate with a common polymorphism in the UMOD region.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Chronic Disease</subject><subject>Clinical Epidemiology</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Humans</subject><subject>Kidney Diseases - genetics</subject><subject>Kidney Diseases - physiopathology</subject><subject>Kidney Diseases - urine</subject><subject>Kidney Diseases, Cystic - genetics</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Motor Proteins - genetics</subject><subject>Mucoproteins - genetics</subject><subject>Mucoproteins - urine</subject><subject>Myosin Heavy Chains - genetics</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Renal failure</subject><subject>Risk Factors</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Uromodulin</subject><issn>1046-6673</issn><issn>1533-3450</issn><issn>1533-3450</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUlPBCEQhYnRuF89Gi7GU4-sTXMxmYxrHJeo45UwQCva3YzQo_Hfi3HicoJQH6-q3gNgB6MBLit8MLy7GhCEJBJIEL4E1jGntKCMo-V8R6wsylLQNbCR0jNCmBMhVsEalpJLgfk6uJnE0AY7b3wHx-7NNQkOUwrG697Bd98_QQ1HoW1DByeX10fwQUevux7qzsJbn15gHSI874y3Lr-OLo62wEqtm-S2F-cmmJwc34_OivH16floOC4Mw7IvqC0rzrQUqOZuao3FpraYMiuFLmUuTJ2eEsYxklKUsuaUsTLvSLFFFZGSboLDb93ZfNo6a3L7qBs1i77V8UMF7dX_Suef1GN4U6TK7jCUBfYXAjG8zl3qVeuTcU2jOxfmSQlKRTawwpkcfJMmhpSiq3-6YKS-UlA5BfWbQv6w-3e2X3xhewb2FoBORjd11NnB9MMRQqWgjNBP6QSOYw</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>KÖTTGEN, Anna</creator><creator>HWANG, Shih-Jen</creator><creator>GUDNASON, Vilmundur</creator><creator>SHLIPAK, Michael G</creator><creator>QIONG YANG</creator><creator>CORESH, Josef</creator><creator>LEVY, Daniel</creator><creator>FOX, Caroline S</creator><creator>LARSON, Martin G</creator><creator>VAN EYK, Jennifer E</creator><creator>QIN FU</creator><creator>BENJAMIN, Emelia J</creator><creator>DEHGHAN, Abbas</creator><creator>GLAZER, Nicole L</creator><creator>LINDA KAO, W. H</creator><creator>HARRIS, Tamara B</creator><general>American Society of Nephrology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100201</creationdate><title>Uromodulin Levels Associate with a Common UMOD Variant and Risk for Incident CKD</title><author>KÖTTGEN, Anna ; HWANG, Shih-Jen ; GUDNASON, Vilmundur ; SHLIPAK, Michael G ; QIONG YANG ; CORESH, Josef ; LEVY, Daniel ; FOX, Caroline S ; LARSON, Martin G ; VAN EYK, Jennifer E ; QIN FU ; BENJAMIN, Emelia J ; DEHGHAN, Abbas ; GLAZER, Nicole L ; LINDA KAO, W. H ; HARRIS, Tamara B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-3d6854a970f5ebdcd1cfd134d97a694a9beab2451099769f5344670731d082993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Chronic Disease</topic><topic>Clinical Epidemiology</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Glomerular Filtration Rate - physiology</topic><topic>Humans</topic><topic>Kidney Diseases - genetics</topic><topic>Kidney Diseases - physiopathology</topic><topic>Kidney Diseases - urine</topic><topic>Kidney Diseases, Cystic - genetics</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Motor Proteins - genetics</topic><topic>Mucoproteins - genetics</topic><topic>Mucoproteins - urine</topic><topic>Myosin Heavy Chains - genetics</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Renal failure</topic><topic>Risk Factors</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Uromodulin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KÖTTGEN, Anna</creatorcontrib><creatorcontrib>HWANG, Shih-Jen</creatorcontrib><creatorcontrib>GUDNASON, Vilmundur</creatorcontrib><creatorcontrib>SHLIPAK, Michael G</creatorcontrib><creatorcontrib>QIONG YANG</creatorcontrib><creatorcontrib>CORESH, Josef</creatorcontrib><creatorcontrib>LEVY, Daniel</creatorcontrib><creatorcontrib>FOX, Caroline S</creatorcontrib><creatorcontrib>LARSON, Martin G</creatorcontrib><creatorcontrib>VAN EYK, Jennifer E</creatorcontrib><creatorcontrib>QIN FU</creatorcontrib><creatorcontrib>BENJAMIN, Emelia J</creatorcontrib><creatorcontrib>DEHGHAN, Abbas</creatorcontrib><creatorcontrib>GLAZER, Nicole L</creatorcontrib><creatorcontrib>LINDA KAO, W. H</creatorcontrib><creatorcontrib>HARRIS, Tamara B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the American Society of Nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KÖTTGEN, Anna</au><au>HWANG, Shih-Jen</au><au>GUDNASON, Vilmundur</au><au>SHLIPAK, Michael G</au><au>QIONG YANG</au><au>CORESH, Josef</au><au>LEVY, Daniel</au><au>FOX, Caroline S</au><au>LARSON, Martin G</au><au>VAN EYK, Jennifer E</au><au>QIN FU</au><au>BENJAMIN, Emelia J</au><au>DEHGHAN, Abbas</au><au>GLAZER, Nicole L</au><au>LINDA KAO, W. H</au><au>HARRIS, Tamara B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Uromodulin Levels Associate with a Common UMOD Variant and Risk for Incident CKD</atitle><jtitle>Journal of the American Society of Nephrology</jtitle><addtitle>J Am Soc Nephrol</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>21</volume><issue>2</issue><spage>337</spage><epage>344</epage><pages>337-344</pages><issn>1046-6673</issn><issn>1533-3450</issn><eissn>1533-3450</eissn><coden>JASNEU</coden><abstract>Common variants in the region of the UMOD gene, which encodes uromodulin (Tamm-Horsfall protein), associate with chronic kidney disease (CKD) and estimated GFR (eGFR). Whether uromodulin levels associate with UMOD variants or with the risk for developing CKD is unknown. We conducted an age- and gender-matched case-control study (n = 200) of incident CKD (eGFR <60 ml/min per 1.73 m(2)) within the Framingham Heart Study (FHS). Baseline urinary uromodulin concentrations were related to case-control status 9.9 yr later and to genotype at rs4293393. As a replication set, we tested the genotype association with uromodulin concentration in the Atherosclerosis Risk in Communities (ARIC) Study (n = 42). Geometric means of uromodulin concentrations were 51% higher in case than in control subjects (P = 0.016). The adjusted odds ratio of CKD per 1-SD higher concentration of uromodulin was 1.72 (95% confidence interval 1.07 to 2.77; P = 0.03) after accounting for CKD risk factors and baseline eGFR. We observed lower urinary uromodulin concentrations per each copy of the C allele at rs4293393 in both cohorts. In summary, elevated uromodulin concentrations precede the onset of CKD and associate with a common polymorphism in the UMOD region.</abstract><cop>Washington, DC</cop><pub>American Society of Nephrology</pub><pmid>19959715</pmid><doi>10.1681/ASN.2009070725</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1046-6673 |
| ispartof | Journal of the American Society of Nephrology, 2010-02, Vol.21 (2), p.337-344 |
| issn | 1046-6673 1533-3450 1533-3450 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2834540 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Aged Aged, 80 and over Biological and medical sciences Case-Control Studies Chronic Disease Clinical Epidemiology Female Genetic Predisposition to Disease - genetics Genotype Glomerular Filtration Rate - physiology Humans Kidney Diseases - genetics Kidney Diseases - physiopathology Kidney Diseases - urine Kidney Diseases, Cystic - genetics Kidneys Male Medical sciences Middle Aged Molecular Motor Proteins - genetics Mucoproteins - genetics Mucoproteins - urine Myosin Heavy Chains - genetics Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Polymorphism, Single Nucleotide - genetics Renal failure Risk Factors Urinary system involvement in other diseases. Miscellaneous Uromodulin |
| title | Uromodulin Levels Associate with a Common UMOD Variant and Risk for Incident CKD |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T16%3A00%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Uromodulin%20Levels%20Associate%20with%20a%20Common%20UMOD%20Variant%20and%20Risk%20for%20Incident%20CKD&rft.jtitle=Journal%20of%20the%20American%20Society%20of%20Nephrology&rft.au=K%C3%96TTGEN,%20Anna&rft.date=2010-02-01&rft.volume=21&rft.issue=2&rft.spage=337&rft.epage=344&rft.pages=337-344&rft.issn=1046-6673&rft.eissn=1533-3450&rft.coden=JASNEU&rft_id=info:doi/10.1681/ASN.2009070725&rft_dat=%3Cproquest_pubme%3E733710481%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733710481&rft_id=info:pmid/19959715&rfr_iscdi=true |