The role of the T cell in autoimmune inflammation

T cells, in particular CD4+ T cells, have been implicated in mediating many aspects of autoimmune inflammation. However, current evidence suggests that the role played by CD4+ T cells in the development of rheumatoid inflammation exceeds that of activated proinflammatory T-helper (Th)1 effector cell...

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Veröffentlicht in:	Arthritis research & therapy 2005-01, Vol.7 Suppl 2 (Suppl 2), p.S4-S14
Hauptverfasser:	Skapenko, Alla, Leipe, Jan, Lipsky, Peter E, Schulze-Koops, Hendrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Animals Anti-Inflammatory Agents - therapeutic use Antibodies, Monoclonal - therapeutic use Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - therapy Autoimmune Diseases - immunology Autoimmune Diseases - therapy Bystander Effect CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Humans Immunoconjugates - therapeutic use Immunologic Factors - therapeutic use Inflammation - immunology Inflammation - therapy Lymphokines - physiology Mice Mice, Transgenic Receptors, Antigen, T-Cell, alpha-beta - analysis Review T-Lymphocyte Subsets - immunology T-Lymphocytes - immunology Th1 Cells - immunology Tumor Necrosis Factor-alpha - antagonists & inhibitors
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