Heme Biosynthesis in Intermittent Acute Porphyria: Decreased Hepatic Conversion of Porphobilinogen to Porphyrins and Increased Delta Aminolevulinic Acid Synthetase Activity

Hepatic conversion of porphobilinogen to porphyrins was less than 50% of control levels in human subjects with the genetic disease, intermittent acute porphyria. This relative block in heme biosynthesis may be relevant to a concomitant 6- to 10-fold elevation in δ -aminolevulinic acid synthetase act...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1970-11, Vol.67 (3), p.1315-1320
Hauptverfasser:	Strand, L. James, Felsher, Bertram F., Redeker, Allan G., Marver, Harvey S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute intermittent porphyria Biological Sciences: Medical Sciences Biosynthesis Enzymes Excretion Hepatocytes Liver Porphyrins Sodium Uroporphyrinogens Variegate porphyria
Online-Zugang:	Volltext
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