Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery

A lipid coated calcium phosphate (LCP) nanoparticle (NP) formulation was developed for efficient delivery of small interfering RNA (siRNA) to a xenograft tumor model by intravenous administration. Based on the previous formulation, liposome-polycation-DNA (LPD), which was a DNA–protamine complex wra...

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Veröffentlicht in:	Journal of controlled release 2010-03, Vol.142 (3), p.416-421
Hauptverfasser:	Li, Jun, Chen, Yun-Ching, Tseng, Yu-Cheng, Mozumdar, Subho, Huang, Leaf
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium - metabolism Calcium phosphate Calcium Phosphates - chemistry Calcium Phosphates - toxicity Cancer Cell Line, Tumor Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - toxicity Cytokines - immunology Drug Carriers - chemistry Drug Carriers - toxicity Drug Compounding Female Gene Silencing - drug effects General pharmacology Injections, Intravenous Lipids - chemistry Lipids - toxicity Luciferases - genetics Medical sciences Mice Mice, Nude Nanoparticle Nanoparticles - chemistry Nanoparticles - toxicity Neoplasms, Experimental - drug therapy Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism PEGylation Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene Glycols - chemistry Polyethylene Glycols - toxicity RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics siRNA Xenograft Model Antitumor Assays
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