Parity-induced decrease in systemic growth hormone alters mammary gland signaling: a potential role in pregnancy protection from breast cancer

Early full-term pregnancy is an effective natural protection against breast cancer in both humans and experimental rodents. The protective effect of an early pregnancy is, in part, linked to changes in circulating hormones that are involved in both normal breast development and breast cancer. For ex...

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Veröffentlicht in:	Cancer prevention research (Philadelphia, Pa.) Pa.), 2010-03, Vol.3 (3), p.312-321
Hauptverfasser:	Dearth, Robert K, Delgado, David A, Hiney, Jill K, Pathiraja, Thushangi, Oesterreich, Steffi, Medina, Dan, Dees, W Les, Lee, Adrian V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Enzyme-Linked Immunosorbent Assay Female Growth Hormone - genetics Growth Hormone - metabolism Immunoblotting Immunoenzyme Techniques Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Mammary Glands, Animal - metabolism Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - prevention & control Parity Pregnancy Pregnancy, Animal Rats Rats, Sprague-Dawley Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction
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