Repair of O4-Alkylthymine by O6-Alkylguanine-DNA Alkyltransferases

O6-Alkylguanine-DNA alkyltransferase (AGT) plays a major role in repair of the cytotoxic and mutagenic lesion O6-methylguanine (m6G) in DNA. Unlike the Escherichia coli alkyltransferase Ogt that also repairs O4-methylthymine (m4T) efficiently, the human AGT (hAGT) acts poorly on m4T. Here we made se...

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Veröffentlicht in:	The Journal of biological chemistry 2010-03, Vol.285 (11), p.8185-8195
Hauptverfasser:	Fang, Qingming, Kanugula, Sreenivas, Tubbs, Julie L., Tainer, John A., Pegg, Anthony E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation - physiology Alkylation Damage Cancer Catalytic Domain Cysteine Cytotoxicity DNA DNA Adducts - metabolism DNA and Chromosomes DNA Damage - physiology DNA Repair - physiology DNA/Damage DNA/Enzymes DNA/Repair Escherichia coli Escherichia coli - genetics Ethane - metabolism Humans Methane - metabolism Mutagenesis - physiology Mutagenesis Mechanisms Mutation N-Methyl-N'-nitro-N-nitrosoguanidine Nucleic Acid/Enzymology Nucleotide excision repair O-Methylguanine-DNA Methyltransferase - chemistry O-Methylguanine-DNA Methyltransferase - genetics O-Methylguanine-DNA Methyltransferase - metabolism Propane - metabolism Protein Structure, Tertiary Thymine - metabolism
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