Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

Objective To investigate the role of matrix metalloproteinase 13 (MMP‐13; collagenase 3) in osteoarthritis (OA). Methods OA was surgically induced in the knees of MMP‐13–knockout mice and wild‐type mice, and mice were compared. Histologic scoring of femoral and tibial cartilage aggrecan loss (0–3 sc...

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Veröffentlicht in:	Arthritis and rheumatism 2009-12, Vol.60 (12), p.3723-3733
Hauptverfasser:	Little, C. B., Barai, A., Burkhardt, D., Smith, S. M., Fosang, A. J., Werb, Z., Shah, M., Thompson, E. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggrecans - metabolism Animals Arthritis, Experimental - enzymology Arthritis, Experimental - genetics Arthritis, Experimental - pathology Calcinosis - pathology Cartilage, Articular - metabolism Cartilage, Articular - pathology Chondrocytes - pathology Femur - pathology Hypertrophy Joints - metabolism Joints - pathology Joints - surgery Male Matrix Metalloproteinase 13 - deficiency Matrix Metalloproteinase 13 - genetics Matrix Metalloproteinase 13 - metabolism Mice Mice, Knockout Osteoarthritis - enzymology Osteoarthritis - genetics Osteoarthritis - pathology Osteophyte - pathology Tibia - pathology
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