Elevated Concentration of Adenosine 3′:5′-cyclic Monophosphate in Intestinal Mucosa after Treatment with Cholera Toxin
A heat-labile factor in cell-free filtrate of a Vibrio cholerae culture induces a marked rise in the wet-weight concentration of adenosine 3′:5′-cyclic monophosphate (cyclic AMP) in the intestinal mucosa of the dog. The increase becomes appreciable 1-1.5 hr after intraluminal administration of the f...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1970-10, Vol.67 (2), p.851-856 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Schafer, David E. Lust, W. David Sircar, Bithi Goldberg, Nelson D. |
| description | A heat-labile factor in cell-free filtrate of a Vibrio cholerae culture induces a marked rise in the wet-weight concentration of adenosine 3′:5′-cyclic monophosphate (cyclic AMP) in the intestinal mucosa of the dog. The increase becomes appreciable 1-1.5 hr after intraluminal administration of the filtrate, about the same time as the onset of intestinal secretion in response to a heat-labile enterotoxin in the filtrate. These results are consistent with the hypothesis that cyclic AMP may be an intermediary in the intestinal secretory response to cholera toxin. |
| doi_str_mv | 10.1073/pnas.67.2.851 |
| format | Article |
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These results are consistent with the hypothesis that cyclic AMP may be an intermediary in the intestinal secretory response to cholera toxin.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.67.2.851</identifier><identifier>PMID: 4331724</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Biological Sciences: Physiology ; Body tissues ; Cholera ; Cholera - metabolism ; Control loops ; Cyclic AMP - analysis ; Cyclic AMP - metabolism ; Dogs ; Enterotoxins ; Enterotoxins - pharmacology ; Freezing ; Intestinal mucosa ; Intestinal Mucosa - analysis ; Intestinal Mucosa - metabolism ; Mucosa ; Physiology ; Secretion ; Tissue samples ; Toxins ; Vibrio - metabolism</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1970-10, Vol.67 (2), p.851-856</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-520f0ccf3301f9e8af9e85e99332ed30ac8d99798499737ecb421918b3b770193</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/67/2.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/60010$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/60010$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4331724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schafer, David E.</creatorcontrib><creatorcontrib>Lust, W. David</creatorcontrib><creatorcontrib>Sircar, Bithi</creatorcontrib><creatorcontrib>Goldberg, Nelson D.</creatorcontrib><title>Elevated Concentration of Adenosine 3′:5′-cyclic Monophosphate in Intestinal Mucosa after Treatment with Cholera Toxin</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>A heat-labile factor in cell-free filtrate of a Vibrio cholerae culture induces a marked rise in the wet-weight concentration of adenosine 3′:5′-cyclic monophosphate (cyclic AMP) in the intestinal mucosa of the dog. The increase becomes appreciable 1-1.5 hr after intraluminal administration of the filtrate, about the same time as the onset of intestinal secretion in response to a heat-labile enterotoxin in the filtrate. These results are consistent with the hypothesis that cyclic AMP may be an intermediary in the intestinal secretory response to cholera toxin.</description><subject>Animals</subject><subject>Biological Sciences: Physiology</subject><subject>Body tissues</subject><subject>Cholera</subject><subject>Cholera - metabolism</subject><subject>Control loops</subject><subject>Cyclic AMP - analysis</subject><subject>Cyclic AMP - metabolism</subject><subject>Dogs</subject><subject>Enterotoxins</subject><subject>Enterotoxins - pharmacology</subject><subject>Freezing</subject><subject>Intestinal mucosa</subject><subject>Intestinal Mucosa - analysis</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Mucosa</subject><subject>Physiology</subject><subject>Secretion</subject><subject>Tissue samples</subject><subject>Toxins</subject><subject>Vibrio - metabolism</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFvFCEYhonR1LX16MVowkVvs_2AmR1o4qHZtNqkjZf1TFiGcWhYGIGprSd_kz_JX1I2u616MSEvh-d9P_jyIvSKwJxAy45Hr9J80c7pnDfkCZoREKRa1AKeohkAbSte0_o5epHSNQCIhsMBOqgZIy2tZ-jHmTM3KpsOL4PXxueosg0ehx6fdsaHZL3B7PfPXydNkUrfaWc1vgo-jENI41Ci2Hp84bNJ2Xrl8NWkQ1JY9dlEvIpG5U0Zi7_bPODlEJyJCq_CrfVH6FmvXDIv9_ch-nJ-tlp-qi4_f7xYnl5Wum5IrhoKPWjdMwakF4arrTRGCMao6RgozTshWsHroqw1el1TIghfs3XbAhHsEH3YzR2n9cZ0uyWdHKPdqHgng7LyX-LtIL-GG0k5K6fk3-_zMXybyppyY5M2zilvwpQkBy5YA7QYq51Rx5BSNP3jGwTktiu57UouWkll6ar43_79sUf3vpzC3-35NvZAH-Kyn5zL5jYX35v_-Ap-vcPXKYf4hwMQYPe8b7RF</recordid><startdate>19701001</startdate><enddate>19701001</enddate><creator>Schafer, David E.</creator><creator>Lust, W. 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David</creatorcontrib><creatorcontrib>Sircar, Bithi</creatorcontrib><creatorcontrib>Goldberg, Nelson D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schafer, David E.</au><au>Lust, W. David</au><au>Sircar, Bithi</au><au>Goldberg, Nelson D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated Concentration of Adenosine 3′:5′-cyclic Monophosphate in Intestinal Mucosa after Treatment with Cholera Toxin</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1970-10-01</date><risdate>1970</risdate><volume>67</volume><issue>2</issue><spage>851</spage><epage>856</epage><pages>851-856</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>A heat-labile factor in cell-free filtrate of a Vibrio cholerae culture induces a marked rise in the wet-weight concentration of adenosine 3′:5′-cyclic monophosphate (cyclic AMP) in the intestinal mucosa of the dog. The increase becomes appreciable 1-1.5 hr after intraluminal administration of the filtrate, about the same time as the onset of intestinal secretion in response to a heat-labile enterotoxin in the filtrate. These results are consistent with the hypothesis that cyclic AMP may be an intermediary in the intestinal secretory response to cholera toxin.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>4331724</pmid><doi>10.1073/pnas.67.2.851</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1970-10, Vol.67 (2), p.851-856 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological Sciences: Physiology Body tissues Cholera Cholera - metabolism Control loops Cyclic AMP - analysis Cyclic AMP - metabolism Dogs Enterotoxins Enterotoxins - pharmacology Freezing Intestinal mucosa Intestinal Mucosa - analysis Intestinal Mucosa - metabolism Mucosa Physiology Secretion Tissue samples Toxins Vibrio - metabolism |
| title | Elevated Concentration of Adenosine 3′:5′-cyclic Monophosphate in Intestinal Mucosa after Treatment with Cholera Toxin |
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