Independent Association Between Obstructive Sleep Apnea and Subclinical Coronary Artery Disease
Obstructive sleep apnea (OSA) is associated with coronary risk factors, but it is unknown if OSA is associated with development of coronary disease. We evaluated the association between OSA and the presence of subclinical coronary disease assessed by coronary artery calcification (CAC). Consecutive...
Gespeichert in:
Veröffentlicht in: | Chest 2008-04, Vol.133 (4), p.927-933 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 933 |
---|---|
container_issue | 4 |
container_start_page | 927 |
container_title | Chest |
container_volume | 133 |
creator | Sorajja, Dan Gami, Apoor S. Somers, Virend K. Behrenbeck, Thomas R. Garcia-Touchard, Arturo Lopez-Jimenez, Francisco |
description | Obstructive sleep apnea (OSA) is associated with coronary risk factors, but it is unknown if OSA is associated with development of coronary disease. We evaluated the association between OSA and the presence of subclinical coronary disease assessed by coronary artery calcification (CAC).
Consecutive patients with no history of coronary disease who underwent electron-beam CT within 3 years of polysomnography between March 1991 and December 2003 were included. OSA was defined by an apnea-hypopnea index (AHI) ≥ 5 events per hour, and patients were grouped by quartiles of AHI severity. Logistic regression modeled the association between OSA severity and presence of CAC.
There were 202 patients (70% male; median age, 50 years; mean body mass index, 32 kg/m2; 8% diabetic; 9% current smokers; 60% hypercholesterolemic; and 47% hypertensive). OSA was present in 76%. CAC was present in 67% of OSA patients and 31% of non-OSA patients (p < 0.001). Median CAC scores (Agatston units) were 9 in OSA patients and 0 in non-OSA patients (p < 0.001). Median CAC score was higher as OSA severity increased (p for trend by AHI quartile < 0.001). With multivariate adjustment, the odds ratio for CAC increased with OSA severity. Using the first AHI quartile as reference, the adjusted odds ratios for the second, third, and fourth quartiles were 2.1 (p = 0.12), 2.4 (p = 0.06), and 3.3 (p = 0.03), respectively.
In patients without clinical coronary disease, the presence and severity of OSA is independently associated with the presence and extent of CAC. OSA identifies patients at risk for coronary disease and may represent a highly prevalent modifiable risk factor. |
doi_str_mv | 10.1378/chest.07-2544 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2831406</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0012369215496813</els_id><sourcerecordid>70487753</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-55f82c3182459adbfc99fe42ebd5cbe2c30c232e33ea812648dbe3a0ca3894953</originalsourceid><addsrcrecordid>eNp1kUFv1DAQhS1ERZfCkSvKBW5pbY8TJxekZVugUqUeCmfLcSZdV1472MlW_fd1m1WBAxePRvPNzPM8Qj4wespANmdmi2k6pbLklRCvyIq1wEqoBLwmK0oZL6Fu-TF5m9IdzTlr6zfkmDW8hlo2K6IufY8j5sdPxTqlYKyebPDFV5zuEX1x3aUpzmayeyxuHOJYrEePutC-L27mzjjrrdGu2IQYvI4PxTpOmMO5TagTviNHg3YJ3x_iCfn17eLn5kd5df39crO-Ko2o2qmsqqHhBrKunOq-G0zbDig4dn1lOswlajhwBEDdMF6Lpu8QNDUamla0FZyQL8vcce522Jv8naidGqPdZVEqaKv-rXi7Vbdhr3gDTNA6D_h8GBDD7znfVO1sMuic9hjmpCQVjZQVZLBcQBNDShGHlyWMqidL1LMlikr1ZEnmP_6t7A998CADnw6ATvmSQ9Te2PTCccplzYFl7mzhtvZ2e28jqrTTzuWxsKy8C3P02jEAJVTLZe6QSwfmy-8tRpWMRW-wz91mUn2w_xH9CDuFu8g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70487753</pqid></control><display><type>article</type><title>Independent Association Between Obstructive Sleep Apnea and Subclinical Coronary Artery Disease</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Sorajja, Dan ; Gami, Apoor S. ; Somers, Virend K. ; Behrenbeck, Thomas R. ; Garcia-Touchard, Arturo ; Lopez-Jimenez, Francisco</creator><creatorcontrib>Sorajja, Dan ; Gami, Apoor S. ; Somers, Virend K. ; Behrenbeck, Thomas R. ; Garcia-Touchard, Arturo ; Lopez-Jimenez, Francisco</creatorcontrib><description>Obstructive sleep apnea (OSA) is associated with coronary risk factors, but it is unknown if OSA is associated with development of coronary disease. We evaluated the association between OSA and the presence of subclinical coronary disease assessed by coronary artery calcification (CAC).
Consecutive patients with no history of coronary disease who underwent electron-beam CT within 3 years of polysomnography between March 1991 and December 2003 were included. OSA was defined by an apnea-hypopnea index (AHI) ≥ 5 events per hour, and patients were grouped by quartiles of AHI severity. Logistic regression modeled the association between OSA severity and presence of CAC.
There were 202 patients (70% male; median age, 50 years; mean body mass index, 32 kg/m2; 8% diabetic; 9% current smokers; 60% hypercholesterolemic; and 47% hypertensive). OSA was present in 76%. CAC was present in 67% of OSA patients and 31% of non-OSA patients (p < 0.001). Median CAC scores (Agatston units) were 9 in OSA patients and 0 in non-OSA patients (p < 0.001). Median CAC score was higher as OSA severity increased (p for trend by AHI quartile < 0.001). With multivariate adjustment, the odds ratio for CAC increased with OSA severity. Using the first AHI quartile as reference, the adjusted odds ratios for the second, third, and fourth quartiles were 2.1 (p = 0.12), 2.4 (p = 0.06), and 3.3 (p = 0.03), respectively.
In patients without clinical coronary disease, the presence and severity of OSA is independently associated with the presence and extent of CAC. OSA identifies patients at risk for coronary disease and may represent a highly prevalent modifiable risk factor.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.07-2544</identifier><identifier>PMID: 18263678</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Biological and medical sciences ; Calcinosis - complications ; Calcinosis - diagnostic imaging ; Calcinosis - pathology ; calcium ; Cardiology. Vascular system ; coronary artery disease ; Coronary Artery Disease - complications ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - pathology ; Coronary heart disease ; Cross-Sectional Studies ; Female ; Heart ; Humans ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; obstructive sleep apnea ; Pneumology ; Polysomnography ; Respiratory system : syndromes and miscellaneous diseases ; Risk Factors ; Severity of Illness Index ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - pathology ; Tomography, X-Ray Computed</subject><ispartof>Chest, 2008-04, Vol.133 (4), p.927-933</ispartof><rights>2008 The American College of Chest Physicians</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c459t-55f82c3182459adbfc99fe42ebd5cbe2c30c232e33ea812648dbe3a0ca3894953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20276231$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18263678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sorajja, Dan</creatorcontrib><creatorcontrib>Gami, Apoor S.</creatorcontrib><creatorcontrib>Somers, Virend K.</creatorcontrib><creatorcontrib>Behrenbeck, Thomas R.</creatorcontrib><creatorcontrib>Garcia-Touchard, Arturo</creatorcontrib><creatorcontrib>Lopez-Jimenez, Francisco</creatorcontrib><title>Independent Association Between Obstructive Sleep Apnea and Subclinical Coronary Artery Disease</title><title>Chest</title><addtitle>Chest</addtitle><description>Obstructive sleep apnea (OSA) is associated with coronary risk factors, but it is unknown if OSA is associated with development of coronary disease. We evaluated the association between OSA and the presence of subclinical coronary disease assessed by coronary artery calcification (CAC).
Consecutive patients with no history of coronary disease who underwent electron-beam CT within 3 years of polysomnography between March 1991 and December 2003 were included. OSA was defined by an apnea-hypopnea index (AHI) ≥ 5 events per hour, and patients were grouped by quartiles of AHI severity. Logistic regression modeled the association between OSA severity and presence of CAC.
There were 202 patients (70% male; median age, 50 years; mean body mass index, 32 kg/m2; 8% diabetic; 9% current smokers; 60% hypercholesterolemic; and 47% hypertensive). OSA was present in 76%. CAC was present in 67% of OSA patients and 31% of non-OSA patients (p < 0.001). Median CAC scores (Agatston units) were 9 in OSA patients and 0 in non-OSA patients (p < 0.001). Median CAC score was higher as OSA severity increased (p for trend by AHI quartile < 0.001). With multivariate adjustment, the odds ratio for CAC increased with OSA severity. Using the first AHI quartile as reference, the adjusted odds ratios for the second, third, and fourth quartiles were 2.1 (p = 0.12), 2.4 (p = 0.06), and 3.3 (p = 0.03), respectively.
In patients without clinical coronary disease, the presence and severity of OSA is independently associated with the presence and extent of CAC. OSA identifies patients at risk for coronary disease and may represent a highly prevalent modifiable risk factor.</description><subject>Biological and medical sciences</subject><subject>Calcinosis - complications</subject><subject>Calcinosis - diagnostic imaging</subject><subject>Calcinosis - pathology</subject><subject>calcium</subject><subject>Cardiology. Vascular system</subject><subject>coronary artery disease</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary heart disease</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>obstructive sleep apnea</subject><subject>Pneumology</subject><subject>Polysomnography</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - pathology</subject><subject>Tomography, X-Ray Computed</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFv1DAQhS1ERZfCkSvKBW5pbY8TJxekZVugUqUeCmfLcSZdV1472MlW_fd1m1WBAxePRvPNzPM8Qj4wespANmdmi2k6pbLklRCvyIq1wEqoBLwmK0oZL6Fu-TF5m9IdzTlr6zfkmDW8hlo2K6IufY8j5sdPxTqlYKyebPDFV5zuEX1x3aUpzmayeyxuHOJYrEePutC-L27mzjjrrdGu2IQYvI4PxTpOmMO5TagTviNHg3YJ3x_iCfn17eLn5kd5df39crO-Ko2o2qmsqqHhBrKunOq-G0zbDig4dn1lOswlajhwBEDdMF6Lpu8QNDUamla0FZyQL8vcce522Jv8naidGqPdZVEqaKv-rXi7Vbdhr3gDTNA6D_h8GBDD7znfVO1sMuic9hjmpCQVjZQVZLBcQBNDShGHlyWMqidL1LMlikr1ZEnmP_6t7A998CADnw6ATvmSQ9Te2PTCccplzYFl7mzhtvZ2e28jqrTTzuWxsKy8C3P02jEAJVTLZe6QSwfmy-8tRpWMRW-wz91mUn2w_xH9CDuFu8g</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Sorajja, Dan</creator><creator>Gami, Apoor S.</creator><creator>Somers, Virend K.</creator><creator>Behrenbeck, Thomas R.</creator><creator>Garcia-Touchard, Arturo</creator><creator>Lopez-Jimenez, Francisco</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080401</creationdate><title>Independent Association Between Obstructive Sleep Apnea and Subclinical Coronary Artery Disease</title><author>Sorajja, Dan ; Gami, Apoor S. ; Somers, Virend K. ; Behrenbeck, Thomas R. ; Garcia-Touchard, Arturo ; Lopez-Jimenez, Francisco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-55f82c3182459adbfc99fe42ebd5cbe2c30c232e33ea812648dbe3a0ca3894953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Calcinosis - complications</topic><topic>Calcinosis - diagnostic imaging</topic><topic>Calcinosis - pathology</topic><topic>calcium</topic><topic>Cardiology. Vascular system</topic><topic>coronary artery disease</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary heart disease</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>obstructive sleep apnea</topic><topic>Pneumology</topic><topic>Polysomnography</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - pathology</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sorajja, Dan</creatorcontrib><creatorcontrib>Gami, Apoor S.</creatorcontrib><creatorcontrib>Somers, Virend K.</creatorcontrib><creatorcontrib>Behrenbeck, Thomas R.</creatorcontrib><creatorcontrib>Garcia-Touchard, Arturo</creatorcontrib><creatorcontrib>Lopez-Jimenez, Francisco</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sorajja, Dan</au><au>Gami, Apoor S.</au><au>Somers, Virend K.</au><au>Behrenbeck, Thomas R.</au><au>Garcia-Touchard, Arturo</au><au>Lopez-Jimenez, Francisco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Independent Association Between Obstructive Sleep Apnea and Subclinical Coronary Artery Disease</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>133</volume><issue>4</issue><spage>927</spage><epage>933</epage><pages>927-933</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Obstructive sleep apnea (OSA) is associated with coronary risk factors, but it is unknown if OSA is associated with development of coronary disease. We evaluated the association between OSA and the presence of subclinical coronary disease assessed by coronary artery calcification (CAC).
Consecutive patients with no history of coronary disease who underwent electron-beam CT within 3 years of polysomnography between March 1991 and December 2003 were included. OSA was defined by an apnea-hypopnea index (AHI) ≥ 5 events per hour, and patients were grouped by quartiles of AHI severity. Logistic regression modeled the association between OSA severity and presence of CAC.
There were 202 patients (70% male; median age, 50 years; mean body mass index, 32 kg/m2; 8% diabetic; 9% current smokers; 60% hypercholesterolemic; and 47% hypertensive). OSA was present in 76%. CAC was present in 67% of OSA patients and 31% of non-OSA patients (p < 0.001). Median CAC scores (Agatston units) were 9 in OSA patients and 0 in non-OSA patients (p < 0.001). Median CAC score was higher as OSA severity increased (p for trend by AHI quartile < 0.001). With multivariate adjustment, the odds ratio for CAC increased with OSA severity. Using the first AHI quartile as reference, the adjusted odds ratios for the second, third, and fourth quartiles were 2.1 (p = 0.12), 2.4 (p = 0.06), and 3.3 (p = 0.03), respectively.
In patients without clinical coronary disease, the presence and severity of OSA is independently associated with the presence and extent of CAC. OSA identifies patients at risk for coronary disease and may represent a highly prevalent modifiable risk factor.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>18263678</pmid><doi>10.1378/chest.07-2544</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0012-3692 |
ispartof | Chest, 2008-04, Vol.133 (4), p.927-933 |
issn | 0012-3692 1931-3543 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2831406 |
source | MEDLINE; Alma/SFX Local Collection |
subjects | Biological and medical sciences Calcinosis - complications Calcinosis - diagnostic imaging Calcinosis - pathology calcium Cardiology. Vascular system coronary artery disease Coronary Artery Disease - complications Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - pathology Coronary heart disease Cross-Sectional Studies Female Heart Humans Logistic Models Male Medical sciences Middle Aged Multivariate Analysis obstructive sleep apnea Pneumology Polysomnography Respiratory system : syndromes and miscellaneous diseases Risk Factors Severity of Illness Index Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - pathology Tomography, X-Ray Computed |
title | Independent Association Between Obstructive Sleep Apnea and Subclinical Coronary Artery Disease |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T07%3A25%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Independent%20Association%20Between%20Obstructive%20Sleep%20Apnea%20and%20Subclinical%20Coronary%20Artery%20Disease&rft.jtitle=Chest&rft.au=Sorajja,%20Dan&rft.date=2008-04-01&rft.volume=133&rft.issue=4&rft.spage=927&rft.epage=933&rft.pages=927-933&rft.issn=0012-3692&rft.eissn=1931-3543&rft.coden=CHETBF&rft_id=info:doi/10.1378/chest.07-2544&rft_dat=%3Cproquest_pubme%3E70487753%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70487753&rft_id=info:pmid/18263678&rft_els_id=S0012369215496813&rfr_iscdi=true |