Brucella abortus Induces the Secretion of Proinflammatory Mediators from Glial Cells Leading to Astrocyte Apoptosis

Central nervous system (CNS) invasion by bacteria of the genus Brucella results in an inflammatory disorder called neurobrucellosis. In this study we present in vivo and in vitro evidence that B. abortus and its lipoproteins activate the innate immunity of the CNS, eliciting an inflammatory response...

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Veröffentlicht in:	The American journal of pathology 2010-03, Vol.176 (3), p.1323-1338
Hauptverfasser:	García Samartino, Clara, Delpino, M. Victoria, Pott Godoy, Clara, Di Genaro, María Silvia, Pasquevich, Karina A, Zwerdling, Astrid, Barrionuevo, Paula, Mathieu, Patricia, Cassataro, Juliana, Pitossi, Fernando, Giambartolomei, Guillermo H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial - pharmacology Apoptosis - drug effects Astrocytes - enzymology Astrocytes - microbiology Astrocytes - pathology Astrocytes - secretion Bacterial Outer Membrane Proteins - pharmacology Biological and medical sciences Brain - drug effects Brain - microbiology Brain - pathology Brucella abortus - drug effects Brucella abortus - physiology Caspases - metabolism Cell Proliferation - drug effects Cells, Cultured Chemokines - secretion Female Hot Temperature Immunohistochemistry Inflammation Mediators - metabolism Investigative techniques, diagnostic techniques (general aspects) Lipopolysaccharides - pharmacology Lipoproteins - pharmacology Medical sciences Mice Mice, Inbred BALB C Microglia - drug effects Microglia - microbiology Microglia - pathology Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Regular Tumor Necrosis Factor-alpha - secretion
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