CCR6 ligands inhibit HIV by inducing APOBEC3G

We have identified a postentry CCR6-dependent mechanism of inhibition of HIV occurring at an early stage of infection mediated by the induction of the host restriction factor apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G). We observed induction of APOBEC3G expression o...

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Veröffentlicht in:	Blood 2010-02, Vol.115 (8), p.1564-1571
Hauptverfasser:	Lafferty, Mark K., Sun, Lingling, DeMasi, Leon, Lu, Wuyuan, Garzino-Demo, Alfredo
Format:	Artikel
Sprache:	eng
Schlagworte:	APOBEC-3G Deaminase Apolipoproteins B - biosynthesis Apolipoproteins B - immunology Biological and medical sciences Cytidine Deaminase - immunology Enzyme Induction - drug effects Enzyme Induction - immunology Hematologic and hematopoietic diseases HIV - immunology HIV - metabolism HIV Infections - immunology HIV Infections - transmission Human viral diseases Humans Immunobiology Infectious diseases Medical sciences Pertussis Toxin - pharmacology Receptors, CCR5 - immunology Receptors, CCR5 - metabolism Receptors, CCR6 - immunology Receptors, CCR6 - metabolism T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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