NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness

Airways display robust NF-kappaB activation and represent targets for anti-inflammatory asthma therapies, but the functional importance of NF-kappaB activation in airway epithelium remains enigmatic. Therefore, transgenic mice were created in which NF-kappaB activation is repressed specifically in a...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-12, Vol.173 (11), p.7003-7009
Hauptverfasser:	Poynter, Matthew E, Cloots, Roy, van Woerkom, Tiest, Butnor, Kelly J, Vacek, Pamela, Taatjes, Douglas J, Irvin, Charles G, Janssen-Heininger, Yvonne M W
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens - administration & dosage Allergens - immunology Animals Antibody Specificity - genetics Bronchial Hyperreactivity - genetics Bronchial Hyperreactivity - immunology Bronchial Hyperreactivity - pathology Chemokines - antagonists & inhibitors Chemokines - biosynthesis Cytokines - antagonists & inhibitors Cytokines - biosynthesis I-kappa B Proteins - genetics Immunoglobulin E - biosynthesis Inflammation - genetics Inflammation - immunology Inflammation - prevention & control Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - metabolism Inflammation Mediators - physiology Lung - immunology Lung - metabolism Lung - pathology Mice Mice, Inbred BALB C Mice, Transgenic Mucus - metabolism NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-kappa B - physiology NF-KappaB Inhibitor alpha Ovalbumin - administration & dosage Ovalbumin - immunology Respiratory Hypersensitivity - genetics Respiratory Hypersensitivity - immunology Respiratory Hypersensitivity - pathology Respiratory Hypersensitivity - prevention & control Respiratory Mucosa - immunology Respiratory Mucosa - metabolism Respiratory Mucosa - pathology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism
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