Activation-induced accumulation of B and T lymphocyte attenuator at the immunological synapse in CD4+ T cells

The surface expression of BTLA and its accumulation at the immunological synapse are tightly regulated by TCR and HVEM stimulation in CD4+ T cells. BTLA, a recently cloned coreceptor expressed on lymphocytes, negatively regulates cell activation by recruiting SHP‐1/SHP‐2. However, the mechanisms tha...

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Veröffentlicht in:	Journal of leukocyte biology 2010-03, Vol.87 (3), p.425-432
Hauptverfasser:	Owada, Takayoshi, Watanabe, Norihiko, Oki, Mie, Oya, Yoshihiro, Saito, Yasushi, Saito, Takashi, Iwamoto, Itsuo, Murphy, Theresa L., Murphy, Kenneth M., Nakajima, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Presenting Cells - drug effects Calcium - pharmacology CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology Cell Line cell‐surface molecules costimulation Golgi Apparatus - drug effects Golgi Apparatus - metabolism Immunological Synapses - drug effects Immunological Synapses - immunology Ionophores - pharmacology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Lysosomes - drug effects Lysosomes - metabolism Membrane Microdomains - drug effects Membrane Microdomains - metabolism Mice Protein Transport - drug effects Receptors, Antigen, T-Cell - metabolism Receptors, Immunologic - immunology Receptors, Signal Transduction, & Genes Receptors, Tumor Necrosis Factor, Member 14 - metabolism T cells Tetradecanoylphorbol Acetate - pharmacology trafficking
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