Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan

To understand the role of mitochondrial uncoupling protein (UCP) in regulating insulin signaling and glucose homeostasis, we created transgenicDrosophila lines with targeted UCP expression in insulin producing cells (IPCs). Increased UCP activity in IPCs results in decreased steady state Ca(2+) leve...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2009-07, Vol.1 (8), p.699-713
Hauptverfasser:	Fridell, Yih-Woei C, Hoh, Melissa, Kréneisz, Orsolya, Hosier, Suzanne, Chang, Chengyi, Scantling, Dane, Mulkey, Daniel K, Helfand, Stephen L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified - genetics Animals, Genetically Modified - metabolism ATP-Binding Cassette Transporters - metabolism Blood Glucose - metabolism Calcium - metabolism Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Female Forkhead Transcription Factors - metabolism Glyburide - metabolism Insulin - metabolism Insulin-Secreting Cells - metabolism Ion Channels - genetics Ion Channels - metabolism KATP Channels - metabolism Longevity Male Membrane Potentials - drug effects Membrane Potentials - physiology Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Neurons - metabolism Phosphatidylinositol 3-Kinases - metabolism Potassium Channels, Inwardly Rectifying - metabolism Priority Research Paper Receptors, Drug - metabolism Signal Transduction Sulfonylurea Receptors Uncoupling Protein 1
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