Brain phenotypes in two FGFR2 mouse models for Apert syndrome

Apert syndrome (AS) is one of at least nine disorders considered members of the fibroblast growth factor receptor (FGFR) ‐1, ‐2, and ‐3–related craniosynostosis syndromes. Nearly 100% of individuals diagnosed with AS carry one of two neighboring mutations on Fgfr2. The cranial phenotype associated w...

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Veröffentlicht in:	Developmental dynamics 2010-03, Vol.239 (3), p.987-997
Hauptverfasser:	Aldridge, Kristina, Hill, Cheryl A., Austin, Jordan R., Percival, Christopher, Martinez‐Abadias, Neus, Neuberger, Thomas, Wang, Yingli, Jabs, Ethylin Wang, Richtsmeier, Joan T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrocephalosyndactylia - genetics Animals Apert syndrome brain Brain - embryology Craniosynostoses - genetics craniosynostosis development Disease Models, Animal Gene Expression Regulation, Developmental Magnetic Resonance Spectroscopy Mice Mice, Inbred C57BL Mice, Transgenic mouse Mutation Phenotype Receptor, Fibroblast Growth Factor, Type 2 - metabolism skull suture Time Factors Tomography, X-Ray Computed - methods
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