Role of Cyclic AMP-Dependent Kinase Response Element-Binding Protein in Recombinant Adeno-Associated Virus-Mediated Transduction of Heart Muscle Cells

Recombinant adeno-associated virus (rAAV) vectors represent a promising approach to gene delivery for clinical use. Published data indicate that rAAV vector genomes persist in vivo as episomal chromatin in the skeletal muscle of nonhuman primates. In this study, we assessed the interconnection betwe...

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Veröffentlicht in:	Human gene therapy 2009-09, Vol.20 (9), p.1005-1012
Hauptverfasser:	DEAN, Jarrod, PLANTE, Jeremy, HUGGINS, Gordon S, SNYDER, Richard O, AIKAWA, Ryuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Brief Reports Cellular signal transduction Chromatin Immunoprecipitation Cyclic adenylic acid Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Dependovirus - classification Dependovirus - genetics Dependovirus - metabolism Dependovirus - physiology Fundamental and applied biological sciences. Psychology Gene therapy Genetic aspects Genetic transformation Genetic Vectors Health. Pharmaceutical industry Heart muscle Humans Immunoblotting Industrial applications and implications. Economical aspects Isoproterenol - pharmacology Medical sciences Methods Mice Mice, Transgenic Myocytes, Cardiac - metabolism Myocytes, Cardiac - virology Phosphorylation Physiological aspects Primates Rats Recombination, Genetic RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Transduction, Genetic Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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