Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila

Active zones (AZs) are presynaptic membrane domains mediating synaptic vesicle fusion opposite postsynaptic densities (PSDs). At the Drosophila neuromuscular junction, the ELKS family member Bruchpilot (BRP) is essential for dense body formation and functional maturation of AZs. Using a proteomics a...

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Veröffentlicht in:	The Journal of cell biology 2010-02, Vol.188 (4), p.565-579
Hauptverfasser:	Owald, David, Fouquet, Wernher, Schmidt, Manuela, Wichmann, Carolin, Mertel, Sara, Depner, Harald, Christiansen, Frauke, Zube, Christina, Quentin, Christine, Körner, Jorg, Urlaub, Henning, Mechtler, Karl, Sigrist, Stephan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biochemistry Cells Drosophila Drosophila melanogaster - embryology Drosophila melanogaster - metabolism Drosophila melanogaster - ultrastructure Drosophila Proteins - metabolism Embryo, Nonmammalian - metabolism Embryos GTPase-Activating Proteins - metabolism Imaging Insects Larvae Locomotion - physiology Longevity - physiology Materials Membranes Mutation Mutation - genetics Neuromuscular Junction - metabolism Neuromuscular Junction - ultrastructure Neurons Neuroscience Neurotransmitters Phenotype Phosphoproteins - metabolism Presynaptic Terminals - metabolism Presynaptic Terminals - ultrastructure Protein Binding Protein Transport Proteins Proteomics Receptors, Glutamate - metabolism Sequence Homology, Amino Acid Synapses Synaptic Potentials
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