Metabolic Control of G1-S Transition: Cyclin E Degradation by p53-Induced Activation of the Ubiquitin-Proteasome System

Cell cycle progression is precisely regulated by diverse extrinsic and intrinsic cellular factors. Previous genetic analysis in Drosophila melanogaster has shown that disruption of the mitochondrial electron transport chain activates a G1–S checkpoint as a result of a control of cyclin E by p53. Thi...

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Veröffentlicht in:	The Journal of cell biology 2010-02, Vol.188 (4), p.473-479
Hauptverfasser:	Mandal, Sudip, Freije, William A., Guptan, Preeta, Banerjee, Utpal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cell cycle Cell cycle proteins Cell lines Cyclin E - metabolism Cyclins Double stranded RNA Drosophila Drosophila melanogaster - cytology Drosophila melanogaster - metabolism Drosophila melanogaster - ultrastructure Drosophila Proteins - metabolism Electron Transport Complex IV - genetics Enzyme Activation Eye - enzymology Eye - pathology Eye - ultrastructure G1 Phase Gene expression regulation Genetics Insects Interphase Metabolism Molecular Sequence Data Mutation - genetics Phenotype Proteases Proteasome Endopeptidase Complex - metabolism Protein Processing, Post-Translational Proteins S Phase Tumor Suppressor Protein p53 - metabolism Ubiquitin - metabolism Untranslated regions Up regulation
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