AMP579 is revealed to be a potent A2b-adenosine receptor agonist in human 293 cells and rabbit hearts

The mixed A 1 /A 2a -adenosine agonist AMP579 given at reperfusion is protective in animal models of myocardial infarction. Receptor-blocking studies have indicated that the protection came from an adenosine receptor (AR), but neither A 1 - nor A 2a -selective agonists could duplicate its protection...

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Veröffentlicht in:	Basic research in cardiology 2010, Vol.105 (1), p.129-137
Hauptverfasser:	Liu, Yanping, Yang, Xiulan, Yang, Xi-Ming, Walker, Sheree, Förster, Karina, Cohen, Michael V., Krieg, Thomas, Downey, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine A2 Receptor Agonists Animals Cardiology Cell Line Female Hemodynamics Humans Imidazoles - pharmacology Imidazoles - therapeutic use In Vitro Techniques Male Medicine Medicine & Public Health Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - prevention & control Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocardium - pathology Original Contribution Pyridines - pharmacology Pyridines - therapeutic use Rabbits Receptor, Adenosine A2B - therapeutic use
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