Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression

The goal of the study is to examine the relationship between the sensor molecules, Hypoxia Inducible Factor-1 (HIF-1), AMP activated Protein Kinase (AMPK) and mammalian Target of Rapamycin (mTOR) in chondrocyte survival and autophagy. We showed that chondrocytes expressed the energy sensor AMPK-1 an...

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Veröffentlicht in:	Pediatric nephrology (Berlin, West) West), 2010-04, Vol.25 (4), p.633-642
Hauptverfasser:	Bohensky, Jolene, Leshinsky, Serge, Srinivas, Vickram, Shapiro, Irving M.
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Antibodies Autophagy Autophagy - drug effects Autophagy - physiology Bone surgery Calcium - metabolism Cartilage Cell death Cell division Cell Line Cell Survival Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - physiology Enzyme Inhibitors - pharmacology Gene Silencing Growth Plate - cytology Growth Plate - enzymology Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kinases Medicine Medicine & Public Health Metabolism Mice Nephrology Original Article Pediatrics Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Reagents Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering - genetics Sensors Thapsigargin - pharmacology TOR Serine-Threonine Kinases Urology
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