A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

Irreversible cell growth arrest, a process termed cellular senescence, is emerging as an intrinsic tumor suppressive mechanism. Oncogene-induced senescence is thought to be invariably preceded by hyperproliferation, aberrant replication, and activation of a DNA damage checkpoint response (DDR), rend...

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Veröffentlicht in:	The Journal of clinical investigation 2010-03, Vol.120 (3), p.681-693
Hauptverfasser:	Alimonti, Andrea, Nardella, Caterina, Chen, Zhenbang, Clohessy, John G, Carracedo, Arkaitz, Trotman, Lloyd C, Cheng, Ke, Varmeh, Shohreh, Kozma, Sara C, Thomas, George, Rosivatz, Erika, Woscholski, Rudiger, Cognetti, Francesco, Scher, Howard I, Pandolfi, Pier Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical research Cancer therapies Carcinogenesis Cell growth Cell Line, Tumor Cell Proliferation Cellular Senescence Disease Models, Animal Disease prevention DNA damage DNA Damage - genetics Embryo, Mammalian - metabolism Fibroblasts Fibroblasts - metabolism Gene Expression Regulation, Neoplastic Genetic aspects Humans Infections Male Mice Mice, Knockout Neoplasm Transplantation Phosphatase Physiological aspects Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - therapy Protein Biosynthesis - genetics Proteins PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Risk factors Senescence Transplantation, Heterologous Tumor proteins Tumor Suppressor Protein p53 - biosynthesis Tumorigenesis
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