Steroid Receptor Coactivator-3/AIB1 Promotes Cell Migration and Invasiveness through Focal Adhesion Turnover and Matrix Metalloproteinase Expression

Steroid receptor coactivator-3 (SRC-3)/AIB1 is a member of the p160 nuclear receptor coactivator family involved in development and cell cycle progression. We previously showed that SRC-3/AIB1 is required for prostate cancer cell proliferation and survival. Here, we reported that the elevated SRC-3/...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-07, Vol.68 (13), p.5460-5468
Hauptverfasser:	JUN YAN, ERDEM, Halime, RILE LI, YI CAI, AYALA, Gustavo, ITTMANN, Michael, YU-LEE, Li-Yuan, TSAI, Sophia Y, TSAI, Ming-Jer
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Carcinoma - genetics Carcinoma - metabolism Carcinoma - pathology Cell Movement - genetics Focal Adhesion Kinase 1 - metabolism Focal Adhesions - metabolism Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic HeLa Cells Humans Male Matrix Metalloproteinase 13 - metabolism Matrix Metalloproteinase 13 - physiology Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 2 - physiology Matrix Metalloproteinases - genetics Matrix Metalloproteinases - metabolism Medical sciences Neoplasm Invasiveness Neoplasm Metastasis Nuclear Receptor Coactivator 3 Pharmacology. Drug treatments Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Signal Transduction - genetics Transcription Factor AP-1 - physiology Transcription Factors - genetics Transcription Factors - physiology Tumor Cells, Cultured Tumors
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