CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain–engineered monoclonal antibody

CD19 is a B cell–specific antigen expressed on chronic lymphocytic leukemia (CLL) cells but to date has not been effectively targeted with therapeutic monoclonal antibodies. XmAb5574 is a novel engineered anti-CD19 monoclonal antibody with a modified constant fragment (Fc)–domain designed to enhance...

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Veröffentlicht in:	Blood 2010-02, Vol.115 (6), p.1204-1213
Hauptverfasser:	Awan, Farrukh T., Lapalombella, Rosa, Trotta, Rossana, Butchar, Jonathan P., Yu, Bo, Benson, Don M., Roda, Julie M., Cheney, Carolyn, Mo, Xiaokui, Lehman, Amy, Jones, Jeffrey, Flynn, Joseph, Jarjoura, David, Desjarlais, John R., Tridandapani, Susheela, Caligiuri, Michael A., Muthusamy, Natarajan, Byrd, John C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - therapeutic use Antibody-Dependent Cell Cytotoxicity - physiology Antigens, CD19 - immunology Apoptosis Blotting, Western Cytotoxicity, Immunologic - immunology Extracellular Signal-Regulated MAP Kinases - metabolism Flow Cytometry Granzymes - metabolism Humans Immunoglobulin Fc Fragments - genetics Immunoglobulin Fc Fragments - immunology Killer Cells, Natural - immunology Leukemia, B-Cell - genetics Leukemia, B-Cell - immunology Leukemia, B-Cell - therapy Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - therapy Lymphoid Neoplasia Phagocytosis Phosphorylation Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism
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